Multipotent stem cells from adult olfactory mucosa
| Autor: | Karisha Jade Splatt, Wayne Murrell, Nicholas Cameron, Chris T. Perry, John Bianco, Bernadette Bellette, Francois Feron, Alan Mackay-Sim, Gabriel Yin Foo Lee, Andrew Roberts Wetzig |
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| Přispěvatelé: | Khrestchatisky, Michel, Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Aging Biopsy Chick Embryo Biology Cell Fusion Mice Olfactory mucosa Olfactory Mucosa Neurosphere medicine Animals Humans Cell Lineage [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Cells Cultured Aged Stem cell transplantation for articular cartilage repair Neurons Multipotent Stem Cells Age Factors Cell Differentiation Epithelial Cells Middle Aged Neural stem cell Hematopoiesis Rats Cell biology medicine.anatomical_structure Multipotent Stem Cell Immunology [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Olfactory ensheathing glia Neuroglia Olfactory epithelium Developmental Biology Adult stem cell |
| Zdroj: | Developmental Dynamics Developmental Dynamics, 2005, 233(2), pp.496-515 |
| ISSN: | 1097-0177 1058-8388 |
| DOI: | 10.1002/dvdy.20360 |
| Popis: | Multipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken embryo. Cloned neurosphere cells show this multipotency. Multipotency was evident without prior culture in vitro: cells dissociated from adult rat olfactory mucosa generate leukocytes when transplanted into bone marrow-irradiated hosts, and cells dissociated from adult mouse olfactory epithelium generated numerous cell types when transplanted into the chicken embryo. It is unlikely that these results can be attributed to hematopoietic precursor contamination or cell fusion. These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease. |
| Databáze: | OpenAIRE |
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