Immunization and Protection against Malaria during Murine Pregnancy
| Autor: | Charles S. Pavia, Carol J. Niederbuhl |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Placenta
Virulence Parasitemia Mice Immune system Phagocytosis Pregnancy Immunity Virology parasitic diseases medicine Animals Pregnancy Complications Infectious Maternal-Fetal Exchange biology Macrophages Immunogenicity Transplacental Plasmodium yoelii medicine.disease biology.organism_classification Malaria Infectious Diseases Immunization Immunology Female Parasitology Disease Susceptibility |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 44:176-182 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1991.44.176 |
| Popis: | Normal and immune mice were evaluated for their ability to resist infection to the rodent malaria parasite, Plasmodium yoelii, during pregnancy. Parasitemia levels were slightly higher and time-to-death shorter in the nonimmunized pregnant group infected with virulent parasites relative to virgin controls. Subinoculation experiments revealed that numerous virulent organisms were present in the placentas of unprotected gravida but were absent from the fetal livers of their conceptuses. It was also found that mice preimmunized with irradiated P. yoelii survived a usually lethal challenge infection during mid-gestation and delivered healthy newborns. Associated with this protection against transplacental spread of parasites was the additional key finding that placental macrophages were as effective as peritoneal exudate cells in phagocytosing parasite derived material in vitro. This murine malaria-pregnancy model should provide new insights on the various factors (virulence, immunogenicity) of microbial infections affecting the fetal-maternal relationship, as well as on the expression of immune effector mechanisms and immunoregulation, during the reproductive process. |
| Databáze: | OpenAIRE |
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