Traditional and new candidate cardiac biomarkers assessed before, early, and late after half marathon in trained subjects
| Autor: | Cristina Vassalle, Serena Del Turco, Laura Sabatino, Giuseppina Basta, Valter Lubrano, Alessandro Pingitore, Concetta Prontera, Pietro Di Cecco, Silvia Masotti |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac troponin Physiology Cardiac biomarkers Galectin 3 Reference range 030204 cardiovascular system & hematology Running 03 medical and health sciences Recovery period 0302 clinical medicine Physiology (medical) Internal medicine Troponin I Medicine Humans Orthopedics and Sports Medicine Trained subjects business.industry Public Health Environmental and Occupational Health Heart 030229 sport sciences General Medicine Human physiology Middle Aged medicine.disease Troponin Heart failure alpha 1-Antitrypsin Cardiology business Biomarkers |
| Zdroj: | European journal of applied physiology. 118(2) |
| ISSN: | 1439-6327 |
| Popis: | Cardiac Troponins (cTnI, cTnT), NT-proBNP, and galectin-3 (GAL-3) mirror cardiomyocyte injury, stretch, and fibrosis. However, although these biomarkers has been thoroughly studied in marathon or ultramarathon, the effects occurring running shorter distances, as half-marathon, are less known and data are generally limited to immediately post-race evaluation. Moreover, significant variation of alpha-1 antitrypsin (AAT), an anti-protease factor with anti-inflammatory properties, has been recently observed in heart failure, but not investigated in paraphysiological settings. The aim of the study was to evaluate these biomarkers concentration and trends in trained runners before half-marathon run and during a 48-h recovery period. In 18 half-marathon runners (15 males, 46 ± 6 years), cTnI, GAL-3 (Architect, Abbott), cTnT, NT-proBNP (Cobas e411, Roche), and AAT (Abcam, Cambridge, UK) were evaluated at rest, immediately post-run, and at 24 and 48-h recovery period. cTnT, NT-proBNP, and GAL-3 transiently increased after post-race, but normalized at 24 h (GAL-3 p |
| Databáze: | OpenAIRE |
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