Oral Administration of Vanillin Improves Imiquimod-Induced Psoriatic Skin Inflammation in Mice
| Autor: | Tin-Yun Ho, Yi-Fang Liao, Feng-Yuan Chen, Chien-Yun Hsiang, Chia-Cheng Li, Hsin-Yi Lo, Hui Man Cheng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Imiquimod Inflammation Pharmacology Interleukin-23 Mice 03 medical and health sciences chemistry.chemical_compound Oral administration Psoriasis medicine Interleukin 23 Animals Humans Skin Mice Inbred BALB C Epidermis (botany) Chemistry Vanillin Interleukin-17 General Chemistry medicine.disease 030104 developmental biology Benzaldehydes Immunology Aminoquinolines Female Interleukin 17 medicine.symptom General Agricultural and Biological Sciences medicine.drug |
| Zdroj: | Journal of Agricultural and Food Chemistry. 65:10233-10242 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.7b04259 |
| Popis: | Vanillin is one of the most widely used flavoring products worldwide. Psoriasis is a chronic inflammatory skin disorder. The interleukin-23 (IL-23)/interleukin-17 (IL-17) axis plays a critical role in psoriasis. Here, we analyzed the effect of vanillin on imiquimod (IMQ)-induced psoriatic skin inflammation in mice. Mice were treated topically with IMQ on the back skin and orally with various amounts of vanillin for 7 consecutive days. Vanillin significantly improved IMQ-induced histopathological changes of skin in a dose-dependent manner. The thickness and number of cell layers of epidermis were reduced by 29 ± 14.4 and 27.8 ± 11%, respectively, in mice given 100 mg/kg of vanillin. A microarray showed that a total of 9042 IMQ-upregulated genes were downregulated by vanillin, and the biological pathways involved in the immune system and metabolism were significantly altered by vanillin. The upregulated expressions of IL-23, IL-17A, and IL-17F genes were suppressed by vanillin, with fold changes of -3.07 ± 0.08, -2.06 ± 0.21, and -1.62 ± 0.21, respectively. Moreover, vanillin significantly decreased both the amounts of IL-17A and IL-23 and the infiltration of immune cells in the skin tissues of IMQ-treated mice. In conclusion, our findings suggested that vanillin was an effective bioactive compound against psoriatic skin inflammation. Moreover, the downregulation of IL-23 and IL-17 expression suggested that vanillin was a novel regulator of the IL-23/IL-17 axis. |
| Databáze: | OpenAIRE |
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