Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest
| Autor: | Jörn Rittweger, Daniel L. Belavý, Heinz J. Roth, Gabriele Armbrecht, Dieter Felsenberg, Petra Frings-Meuthen, Natalie Baecker, Gisela Beller, Martina Heer, Judith Buehlmeier |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Genetic Markers Male medicine.medical_specialty animal structures Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment chemistry.chemical_element 030209 endocrinology & metabolism Calcium Bed rest Bone resorption 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Bone Density Osteogenesis Internal medicine medicine Bone mineral density Humans Immobilisation Training Orthopedics and Sports Medicine Femur Exercise pQCT Adaptor Proteins Signal Transducing Proximal femur business.industry Osteoblast General Medicine Spaceflight 030104 developmental biology medicine.anatomical_structure chemistry DKK1 embryonic structures Bone Morphogenetic Proteins Bone mineral content Sclerostin Intercellular Signaling Peptides and Proteins business Bed Rest Biomarkers |
| DOI: | 10.1007/s00774-015-0681-3 |
| Popis: | The impact of effective exercise against bone loss during experimental bed rest appears to be associated with increases in bone formation rather than reductions of bone resorption. Sclerostin and dickkopf-1 are important inhibitors of osteoblast activity. We hypothesized that exercise in bed rest would prevent increases in sclerostin and dickkopf-1. Twenty-four male subjects performed resistive vibration exercise (RVE; n = 7), resistive exercise only (RE; n = 8), or no exercise (control n = 9) during 60 days of bed rest (2nd Berlin BedRest Study). We measured serum levels of BAP, CTX-I, iPTH, calcium, sclerostin, and dickkopf-1 at 16 time-points during and up to 1 year after bed rest. In inactive control, after an initial increase in both BAP and CTX-I, sclerostin increased. BAP then returned to baseline levels, and CTX-I continued to increase. In RVE and RE, BAP increased more than control in bed rest (p ≤ 0.029). Increases of CTX-I in RE and RVE did not differ significantly to inactive control. RE may have attenuated increases in sclerostin and dickkopf-1, but this was not statistically significant. In RVE there was no evidence for any impact on sclerostin and dickkopf-1 changes. Long-term recovery of bone was also measured and 6–24 months after bed rest, and proximal femur bone mineral content was still greater in RVE than control (p = 0.01). The results, while showing that exercise against bone loss in experimental bed rest results in greater bone formation, could not provide evidence that exercise impeded the rise in serum sclerostin and dickkopf-1 levels. |
| Databáze: | OpenAIRE |
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