Eight‐week exercise training in humans with obesity: Marked improvements in insulin sensitivity and modest changes in gut microbiome
| Autor: | Hauke Smidt, Prokopis Konstanti, Ad R. M. M. Hermus, Dick H. J. Thijssen, Rebecca J. H. M. Verheggen, Maria T. E. Hopman |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
food.ingredient Endocrinology Diabetes and Metabolism Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Medicine (miscellaneous) Type 2 diabetes Gut flora Microbiology RC1200 Endocrinology food Anaerostipes Microbiologie RNA Ribosomal 16S Internal medicine medicine Life Science Humans Aerobic exercise MolEco Obesity Exercise VLAG WIMEK Nutrition and Dietetics biology business.industry Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6] Lachnospiraceae VO2 max Cardiorespiratory fitness Middle Aged medicine.disease biology.organism_classification R1 Gastrointestinal Microbiome Diabetes Mellitus Type 2 Insulin Resistance business Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| Zdroj: | Obesity, 29, 10, pp. 1615-1624 Obesity, 29(10), 1615-1624 Obesity 29 (2021) 10 Obesity, 29, 1615-1624 |
| ISSN: | 1930-739X 1930-7381 |
| DOI: | 10.1002/oby.23252 |
| Popis: | Contains fulltext : 237734.pdf (Publisher’s version ) (Open Access) OBJECTIVE: Obesity is associated with impaired gut microbiota diversity, which has been linked to the development of type 2 diabetes. This study aims to examine the effects of an 8-week aerobic exercise intervention on insulin sensitivity, visceral adiposity, and gut microbiota diversity and composition in participants with obesity. METHODS: Fourteen participants (mean [SD], age 51 [11] years; BMI 34.9 [4.9] kg/m(2) ) performed an 8-week exercise intervention (2 to 4 times/week on 65% to 85% of heart rate reserve). Insulin sensitivity (hyperinsulemic euglycemic clamp), cardiorespiratory fitness (maximal oxygen uptake), visceral adiposity (dual-energy X-ray absorptiometry scan) and gut microbiota composition (16S rRNA gene sequencing) were measured before and after the intervention. RESULTS: Insulin sensitivity showed a significant increase (pre: 3.8 [1.9] mg/min/kg; post: 4.5 [1.7] mg/min/kg; p = 0.007) after training, whereas visceral adiposity decreased (pre: 959 [361] cm(3) ; post: 897 [364] cm(3) ; p = 0.02). No change in gut microbiota α- or β-diversity was found. At the genus level, the abundance of Ruminococcus gauvreauii (p = 0.02); Lachnospiraceae FCS020 group (p = 0.04), and Anaerostipes (p = 0.04) significantly increased after exercise training. Significant positive correlations were present for M-value (R. gauvreauii) and VO(2) max (R. gauvreauii and Anaerostipes). CONCLUSIONS: Eight-week exercise training in humans with obesity leads to marked improvements in insulin sensitivity and body composition and is accompanied by modest changes in 3 gut microbiome genera, all belonging to the Firmicutes phylum. |
| Databáze: | OpenAIRE |
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