Effects of candesartan cilexetil on carotid remodeling in hypertensive diabetic patients: the MITEC study

Autor: Paul Valensi, R. Asmar, JM Mallion, Sophie Nisse-Durgeat, Jean-Philippe Baguet
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Carotid Artery Diseases
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Endocrinology
Diabetes and Metabolism
Tetrazoles
Blood Pressure
Type 2 diabetes
amlodipine
Essential hypertension
Hydrochlorothiazide
Pharmacology (medical)
Diuretics
Original Research
Ultrasonography
diabetes
Hematology
General Medicine
Middle Aged
Calcium Channel Blockers
Biphenyl compound
Treatment Outcome
Disease Progression
Female
France
Tunica Media
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
hypertension
Carotid Artery
Common
Urology
Diabetic angiopathy
candesartan
Double-Blind Method
Internal medicine
medicine
Humans
Amlodipine
intima-media thickness
Antihypertensive Agents
Aged
business.industry
Biphenyl Compounds
Public Health
Environmental and Occupational Health
medicine.disease
carotid
Candesartan
Endocrinology
Blood pressure
Diabetes Mellitus
Type 2
lcsh:RC666-701
Benzimidazoles
Tunica Intima
business
Angiotensin II Type 1 Receptor Blockers
Diabetic Angiopathies
Zdroj: Vascular Health and Risk Management, Vol 2009, Iss default, Pp 175-183 (2009)
Vascular Health and Risk Management
ISSN: 1178-2048
1176-6344
Popis: JP Baguet1, R Asmar2, P Valensi3, S Nisse-Durgeat4, JM Mallion11Clinique de Cardiologie, CHU de Grenoble, Grenoble, France; 2Institut CardioVasculaire, Paris, France; 3Service d’Endocrinologie-Diabétologie-Nutrition, CHU Jean Verdier, AP-HP, Bondy, France; 4Laboratoires Takeda, Puteaux, FranceAbstract: In hypertension and diabetes, early structural changes of the arterial wall precede or support atherosclerosis. There is evidence that some antihypertensive drugs exert an antiatherosclerotic effect. Over 36 months, we investigated the effect of candesartan cilexetil (CC) on the common carotid intima-media thickness (IMT) vs amlodipine besylate (AML) in patients with type 2 diabetes and mild to moderate essential hypertension. After a 4-week wash-out period, 209 patients were randomized to either CC 8 mg or AML 5 mg once daily for a minimum of 1 month, after which, if BP was not normalized, the dosage was doubled, followed by the addition of hydrochlorothiazide 12.5 mg if necessary. No significant differences were observed between the two groups for change in IMT at M12 (−0.001 vs −0.027 mm/year for CC and AML respectively, p = 0.425), at M24 (−0.033 vs −0.019 mm per year respectively, p = 0.442), and at the last visit (−0.016 vs −0.039 mm per year respectively, p = 0.549). Within the group, comparisons did not show a significant difference in changes in IMT from baseline to the three visits. At the last visit, IMT regression was observed in 52.2% of patients receiving CC and in 51.3% of those receiving AML (p = 0.908). The augmentation in carotid lumen diameter from baseline was statistically greater in the AML group at the last visit (p = 0.034). BP variations during the study were similar in the two groups. The results of this study show that CC and AML treatments may alter identically the natural progression of carotid IMT in hypertensive type 2 diabetic patients.Keywords: hypertension, diabetes, carotid, intima-media thickness, candesartan, amlodipine
Databáze: OpenAIRE
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