Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial
| Autor: | Jenny E. Gunton, Christian M. Girgis, Lindy Begg, Victoria M Flood, Timothea Lau, Mauro Vicaretti |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Vitamin
medicine.medical_specialty medicine.medical_treatment Placebo-controlled study Medicine (miscellaneous) Ascorbic Acid law.invention chemistry.chemical_compound Randomized controlled trial law Diabetes mellitus Internal medicine medicine Humans Ulcer Wound Healing Nutrition and Dietetics Vitamin C business.industry Osteomyelitis Vitamins medicine.disease Diabetic Foot chemistry Amputation business Foot (unit) |
| Zdroj: | The British journal of nutrition. 126(10) |
| ISSN: | 1475-2662 |
| Popis: | Chronic foot ulcers are associated with a high risk of osteomyelitis, poor quality of life, amputations and disability. Few strategies improve their healing, and amputation rates in high-risk foot services are usually over 30 %. We conducted a randomised, inactive-placebo controlled, double-blind trial of 500 mg of slow-release vitamin C in sixteen people with foot ulcers in the Foot Wound Clinic at Westmead Hospital. Nine were randomised to control and seven to vitamin C. When serum vitamin C results become available at 4 weeks, all people with deficiency were offered both vitamin C and glucosamine tablets for the next 4 weeks. Patients without baseline deficiency continued their original assigned treatment. The primary outcome was percentage ulcer healing (reduction in ulcer size) at 8 weeks. Fifty percentage of subjects had baseline vitamin C deficiency, half having undetectable levels. Healing at 8 weeks was significantly better in the vitamin C group (median 100 v. –14 %, P = 0·041). Healing without amputation occurred in all patients in the vitamin C group. In contrast, 44 % of controls had not healed their ulcer at the end of the study period. Vitamin C improved healing of foot ulcers. Further studies are needed to determine whether there is a threshold effect for serum vitamin C above which therapy is ineffective and whether there are better or lesser responding subgroups. Because of its low cost and ease of access and administration, we recommend offering vitamin C therapy to all people who have chronic foot ulcers and potentially suboptimal vitamin C intake. Trial registration number: ACTRN12617001142325. |
| Databáze: | OpenAIRE |
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