Metal-organic frameworks for advanced drug delivery
| Autor: | Ruxandra Gref, Jiwen Zhang, Siyu He, Huimin Sun, Xue Li, Hongyu Sun, Weidong Chen, Li Wu, Ting Xiong, Huipeng Xu, Jie Liu, Chengxi Huang |
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| Přispěvatelé: | Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Crystalline materials Nanotechnology RM1-950 Review Drug loading Biopharmaceutics Synthesis and characterization 03 medical and health sciences 0302 clinical medicine Highly porous [CHIM]Chemical Sciences Biosafety General Pharmacology Toxicology and Pharmaceutics ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Pharmaceutics Metal-organic frameworks Drug delivery systems 3. Good health 030220 oncology & carcinogenesis Diseases therapy Drug delivery Metal-organic framework Therapeutics. Pharmacology Metal clusters |
| Zdroj: | Acta Pharmaceutica Sinica B Acta Pharmaceutica Sinica B, Elsevier, 2021, 11 (8), pp.2362-2395. ⟨10.1016/j.apsb.2021.03.019⟩ Acta Pharmaceutica Sinica. B Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2362-2395 (2021) |
| ISSN: | 2211-3835 |
| Popis: | Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature. Graphical abstract This review focuses on metal–organic frameworks (MOFs)-based drug delivery systems (DDSs), including classification, synthesis, characterization, applications and biopharmaceutics of MOFs for DDSs.Image 1 |
| Databáze: | OpenAIRE |
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