The Potential of Systemic Control of Sand Flies Using Fipronil in the Novel Leishmania major (Kinetoplastida: Trypanosomatidae) Reservoirs Meriones tristrami (Rodentia: Muridea) and Meriones crassus (Rodentia: Muridea)
| Autor: | Zvika Abramsky, Ido Tsurim, Gil Ben Natan, Gideon Wasserberg |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Meriones crassus Veterinary medicine Insecticides 030231 tropical medicine Leishmaniasis Cutaneous 01 natural sciences Insect Control 03 medical and health sciences Meriones tristrami chemistry.chemical_compound 0302 clinical medicine medicine Animals Humans Leishmania major Israel Feces Fipronil Disease Reservoirs General Veterinary biology Kinetoplastida Leishmaniasis medicine.disease biology.organism_classification 010602 entomology Infectious Diseases chemistry Insect Science Vector (epidemiology) Pyrazoles Parasitology Psychodidae Gerbillinae |
| Zdroj: | Journal of medical entomology. 58(2) |
| ISSN: | 1938-2928 |
| Popis: | Leishmania major (Yakimoff & Schokhor, 1914), an important causative agent of Old World Cutaneous Leishmaniasis (CL), is transmitted by sand flies among a limited number of gerbilline reservoir-species. We can take advantage of this strong dependency to break the pathogen transmission cycle by using systemic insecticides that render the host toxic to the blood-feeding vector. We evaluated the potential of this approach with two novel reservoir species, incriminated for CL expansion in several sites in the Middle East. Specifically, we evaluated: 1) the residuality of the systemic insecticide fipronil in Meriones tristrami (Thomas, 1892) fed on fipronil-treated baits and 2) the treatments’ adulticide effect on sand flies that blood fed on treated and untreated M. tristrami and M. crassus (Sundevall, 1842). We fed M. tristrami with food pellets containing 0.1 g/kg fipronil and used gas chromatograph–mass spectrometery analysis and bioassays to examine its residual toxicity to blood-feeding female sand flies. In M. tristrami, fipronil was rapidly metabolized to fipronil sulfone, found in the blood, urine, and feces for ≥31 d after fipronil admission. The survival of sand flies that blood fed on fipronil-treated M. tristrami and M. crassus was significantly reduced for at least 15 and 9 d respectively, after fipronil admission. These results hold promise for the potential contribution of systemic control approaches to CL integrated management strategies against novel CL (due to L. major) outbreaks in Israel and elsewhere. |
| Databáze: | OpenAIRE |
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