Efficacy of 7-Day and 14-Day Bismuth-Containing Quadruple Therapy and 7-Day and 14-Day Moxifloxacin-Based Triple Therapy as Second-Line Eradication for Helicobacter pylori Infection
| Autor: | Young Soo Park, Cheol Min Shin, Dong Ho Lee, Ji Hyun Lim, In Sung Song, Seong tae Lee, Nayoung Kim, Hyun Jin Jo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Moxifloxacin-based triple regimen medicine.medical_specialty Helicobacter pylori infection Moxifloxacin Gastroenterology Drug Administration Schedule Helicobacter Infections Bismuth-containing quadruple regimen Second line Anti-Infective Agents Metronidazole Internal medicine medicine Humans Aged Retrospective Studies Intention-to-treat analysis Helicobacter pylori Hepatology biology business.industry Amoxicillin Proton Pump Inhibitors Middle Aged Tetracycline bacterial infections and mycoses biology.organism_classification Intention to Treat Analysis Regimen Treatment Outcome Original Article Drug Therapy Combination Female Antacids business Second-line therapy Bismuth Fluoroquinolones medicine.drug |
| Zdroj: | Gut and Liver |
| ISSN: | 2005-1212 1976-2283 |
| DOI: | 10.5009/gnl14020 |
| Popis: | Background/Aims Bismuth-containing quadruple and moxifloxacin-based triple regimens are recommended as second-line therapy for Helicobacter pylori infection. The aim of this study was to compare the efficacy of each regimen. Methods From August 2004 to October 2012, a total of 949 patients (mean age, 54.32±12.08 years; male, 49.4%) who failed H. pylori eradication with a standard triple regimen were included. Patients treated with a bismuth-containing quadruple regimen for 7 and 14 days were designated as 7-BMT and 14-BMT, respectively, and those treated with a moxifloxacin-based triple regimen for 7 and 14 days were designated as 7-MA and 14-MA, respectively. H. pylori eradication was confirmed using the 13C-urea breath test, rapid urease test or histology. Results The eradication rates by 7-BMT, 14-BMT, 7-MA, and 14-MA were 66.4% (290/437), 71.1% (113/159), 53.1% (51/96), and 73.5% (189/257), respectively, by intention-to-treat analysis (ITT) and 76.5% (284/371), 83.8% (109/130), 55.6% (50/90), and 80.6% (187/232), respectively, by per-protocol analysis (PP). The eradication rates were higher in 14-BMT than 7-BMT by the ITT and PP analyses (p=0.277 and p=0.082, respectively). The 14-BMT and 14-MA treatments showed similar efficacies by ITT and PP (p=0.583 and p=0.443, respectively). Conclusions The 7-BMT, 14-BMT, and 14-MA treatments showed similar and suboptimal efficacies. In both regimens, extending the duration of treatment may be reasonable considering the high level of antibiotic resistance in Korea. |
| Databáze: | OpenAIRE |
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