Revised interpretation of oxacillin MICs for Staphylococcus epidermidis based on mecA detection
| Autor: | C L McDonald, Robert J. Fass, W E Maher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Micrococcaceae
Genotype medicine.drug_class Antibiotics Microbial Sensitivity Tests medicine.disease_cause Methicillin resistance Microbiology Minimum inhibitory concentration Bacterial Proteins Staphylococcus epidermidis medicine polycyclic compounds Pharmacology (medical) University medical Antibacterial agent Oxacillin Pharmacology biology biochemical phenomena metabolism and nutrition biology.organism_classification Infectious Diseases Staphylococcus aureus bacteria Research Article |
| Popis: | In 1992 and 1993, at The Ohio State University Medical Center, a larger proportion of Staphylococcus epidermidis strains required oxacillin MICs of 1 to 2 micrograms/ml than did Staphylococcus aureus strains. mecA genotype was correlated with antimicrobial susceptibility for selected clinical S. epidermidis strains. All 14 strains that required oxacillin MICs of < or = 0.25 microgram/ml and 2 of 5 strains that required oxacillin MICs of 0.5 microgram/ml were susceptible by 1-microgram oxacillin disk test and were mecA negative. Three of 5 strains that required oxacillin MICs of 0.5 microgram/ml and all 18 strains that required oxacillin MICs of > or = 1.0 microgram/ml were resistant by oxacillin disk test and were mecA positive. Current National Committee for Clinical Laboratory Standards MIC interpretive criteria may underestimate methicillin resistance among S. epidermidis strains. |
| Databáze: | OpenAIRE |
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