HPA-axis and inflammatory reactivity to acute stress is related with basal HPA-axis activity

Autor: Luke Hanlin, Nicolas Rohleder, Alexander Fiksdal, Danielle Gianferante, Juliana G. Breines, Myriam V. Thoma, Xuejie Chen
Přispěvatelé: University of Zurich, Rohleder, Nicolas
Rok vydání: 2017
Předmět:
Adult
Male
Hypothalamo-Hypophyseal System
endocrine system
medicine.medical_specialty
Saliva
Cortisol awakening response
Adolescent
Hydrocortisone
Endocrinology
Diabetes and Metabolism
Pituitary-Adrenal System
Article
2738 Psychiatry and Mental Health
Young Adult
03 medical and health sciences
Basal (phylogenetics)
0302 clinical medicine
Endocrinology
Internal medicine
Trier social stress test
medicine
Humans
Wakefulness
Habituation
Biological Psychiatry
Inflammation
10093 Institute of Psychology
Interleukin-6
Endocrine and Autonomic Systems
Middle Aged
1310 Endocrinology
030227 psychiatry
Peripheral
2712 Endocrinology
Diabetes and Metabolism
2807 Endocrine and Autonomic Systems
Psychiatry and Mental health
Female
150 Psychology
Psychology
2803 Biological Psychiatry
Biomarkers
Stress
Psychological
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
medicine.drug
Zdroj: Psychoneuroendocrinology. 78:168-176
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2017.01.035
Popis: Introduction Inflammation is drawing attention as pathway between psychosocial stress and health, and basal HPA axis activity has been suggested to exert a consistent regulatory influence on peripheral inflammation. Here we studied the relationship between basal HPA axis activity and inflammatory and HPA axis acute stress reactivity. Methods We recruited 48 healthy individuals and collected saliva for diurnal cortisol sampling at 6 points. Participants were previously exposed to the Trier Social Stress Test (TSST) on two consecutive days. Plasma interleukin-6 (IL-6) and salivary cortisol reactivity to acute stress were measured, and their relationships with basal HPA axis activity were analyzed. Results Steeper cortisol awakening response (CAR) linear increase was related with stronger cortisol stress reactivity (γ = 0.015; p = 0.042) and marginally significantly with greater habituation (γ = 0.01; p = 0.066). Greater curvilinearity of CAR was related with stronger cortisol reactivity (γ = −0.014; p = 0.021) and greater cortisol habituation (γ = −0.011; p = 0.006). Steeper daily linear decline was related with significant or marginally significantly stronger cortisol and IL-6 reactivity (cortisol: γ = −0.0004; p = 0.06; IL-6: γ = −0.028; p = 0.031) and greater habituation (cortisol: γ = −0.002; p = 0.009, IL-6: γ = −0.015; p = 0.033). Greater curvilinearity of daily decline was related with stronger IL-6 reactivity (γ = 0.002; p = 0.024) and also greater cortisol and IL-6 habituation (cortisol: γ = 0.00009; p = 0.03, IL-6: γ = 0.001; p = 0.024). Conclusions Patterns of basal HPA axis activity that are related with healthier outcomes were found to be related with stronger initial cortisol and IL-6 reactivity and greater habituation. This is an important step in understanding the long-term health implications of acute stress responsiveness, and future studies should employ longitudinal designs to identify the direction of these relationships.
Databáze: OpenAIRE
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