A repeated-dose model of percutaneous drug absorption

Autor:	S.A. Matar, K. Kubota, F. Dey, E. H. Twizell
Rok vydání:	2002
Předmět:	Percutaneous Materials science Dose model Capillary action Modeling and Simulation Modelling and Simulation Applied Mathematics Physics::Medical Physics Percutaneous absorption Flux Linear partial differential equations Biomedical engineering
Zdroj:	Applied Mathematical Modelling. 26(4):529-544
ISSN:	0307-904X
DOI:	10.1016/s0307-904x(01)00068-3
Popis:	A mathematical model is developed for percutaneous absorption with regular applications of the drug. The linear partial differential equations (PDEs) of the model are solved using a finite-difference method which is second-order accurate in space and time. The solutions of these PDEs give the concentrations of the drug in the vehicle and the skin at a given time. The numerical results obtained are adapted to monitor the amount of drug released from the vehicle, the bio-availability for each application, the amount of drug in the skin at a given time, and the flux from the skin to the capillary at a given time.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe16a8ca263a9c6735f5068825b67140 Zobrazit plný text záznamu Full Text from ScienceDirect