Which predilatation balloons provide the best lesion preparation prior to use of drug coated balloons in de-novo lesions? Results from the PREPARE study
| Autor: | Sandeep, Basavarajaiah, Vinoda, Sharma, Dante, Agip-Fustamante, Santiago J, Camacho Freire, Rami, El-Mokdad, Gurbir, Bhatia, Bhagya H, Loku Waduge, Alfonso, Ielasi, José F, Díaz Fernández, Sampath, Athukorala, Bernardo, Cortese |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Minerva Cardiology and Angiology. 71 |
| ISSN: | 2724-5772 2724-5683 |
| Popis: | There is a lack of data on the clinical outcomes following the use of different strategies for lesion preparation prior to the use of drug-coated balloons (DCB). In this study, we have explored the clinical outcomes between different types of pre-dilatation balloons: semicompliant (SB), non-compliant (NB) and scoring balloons (ScB) used when preparing denovo lesions prior to the use of DCB.We retrospectively evaluated all patients who underwent treatment with DCB for de-novo lesions between 2011-2019 at 4 high-volume European centres. The measured study endpoints were: cardiac-death, TV-MI, TLR and MACE.During the study period, 553 patients were treated with DCB for de-novo lesions, 327 with SB only, 172 with NB and 54 with ScB. There were some differences in the procedural characteristics between the 3 groups. Pre-dilatation balloons were significantly larger in the ScB and NB groups as compared to the SB (2.7 mm and 2.6 mm vs. 2.3 mm; p0.001). The reference vessel diameter was significantly larger in the NB group as compared to the ScB and SB (2.6 mm vs. 2.2 mm and 2.3 mm; p0.001). During the median follow-up duration of 547-days, there were no differences in the hard-clinical end-points, however, TLR was significantly higher in the ScB as compared to SB and NB group (11% vs. 3.4% and 4.7%; p=0.02).The PREPARE study results do not suggest routine use of ScB prior to DCB in de novo lesions. |
| Databáze: | OpenAIRE |
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