Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature

Autor: Noelia Martínez-Jañez, Ignacio Pinilla-Pagnon, Lourdes Peña-Jaimes, Irene González-García, Belén Pérez-Mies, María Eugenia Reguero-Callejas, Juan Manuel Rosa-Rosa, Víctor Albarrán-Artahona, José Palacios
Rok vydání: 2018
Předmět:
0301 basic medicine
Pathology
T-Lymphocytes
DNA Mutational Analysis
Lobular carcinoma
Osteoclasts
Case Report
Giant Cells
Breast cancer
0302 clinical medicine
Nuclear atypia
skin and connective tissue diseases
Mastectomy
General Medicine
Cadherins
Immunohistochemistry
Osteoclast-like giant cells
Treatment Outcome
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Invasive lobular carcinoma
Keratins
Female
Breast carcinoma
lcsh:RB1-214
medicine.medical_specialty
Histology
Stromal cell
Breast Neoplasms
Biology
Pathology and Forensic Medicine
03 medical and health sciences
Lymphocytes
Tumor-Infiltrating
Antigens
CD
Pleomorphic carcinoma
lcsh:Pathology
Biomarkers
Tumor
medicine
Humans
neoplasms
Aged
medicine.disease
body regions
Carcinoma
Lobular
030104 developmental biology
Giant cell
Mutation
Pleomorphism (microbiology)
Zdroj: Diagnostic Pathology
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Diagnostic Pathology, Vol 13, Iss 1, Pp 1-6 (2018)
ISSN: 1746-1596
DOI: 10.1186/s13000-018-0744-6
Popis: Background Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphological variant of invasive lobular carcinoma characterized by higher nuclear atypia and pleomorphism than the classical type. In the best of our knowledge, a PLC with OGCs has not been previously reported. Case presentation We report the case of a 72-year-old woman presenting with a pleomorphic tumor of the left breast with a dense infiltration by OGCs and T lymphocytes with a 10:1 predominance of CD8+ over CD4+ cells. The diagnosis of a lymphoid or mesenchymal neoplasia was excluded after demonstrating keratin expression by the neoplastic cells. The absence of E-cadherin expression and the morphological features were consistent with the diagnosis PLC with OGCs. In addition, we demonstrated the deleterious mutation C.del866C in CDH1gene, but no mutations in any of the other 33 genes analyzed by next generation sequencing. Conclusions Breast carcinoma with stromal osteoclast-like giant cells is a very rare tumor, for that reason, the use of the cytologic features and growth patterns in combination with immunohistochemically studies is mandatory for a correct diagnosis of lobular carcinoma. In addition, further studies are necessary to clarify the influence of OGCs in the prognosis of these patients. Electronic supplementary material The online version of this article (10.1186/s13000-018-0744-6) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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