Maximum volume of nasal administration using a mucosal atomization device without aspiration in Japanese White rabbits
| Autor: | Yixian, Wei, Ai, Hori, I-Ying, Chen, Haruka, Tamogi, Taku, Hirokawa, Keiko, Kato, Takaharu, Itami, Tadashi, Sano, Kazuto, Yamashita |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Veterinary Medical Science. 84:792-798 |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.21-0648 |
| Popis: | Recently, a mucosal atomization device (MAD) has been applied in veterinary medicine. In the present study, the maximum volume of nasal atomization without aspiration using MAD was examined in eight healthy female Japanese White (JW) rabbits. Each rabbit had their head and neck examined by computed tomography before and after nasal atomization with four different doses (0.15, 0.3, 0.45, and 0.6 ml per nostril) of diluted contrast medium (1:2 mixture of iohexol and saline). This was done under general anesthesia by an intramuscular administration of alfaxalone 2.5 mg/kg, medetomidine 40 μg/kg, and butorphanol 0.4 mg/kg, with a 7-day washout period between each treatment. The diluted contrast medium was distributed in the nasal cavity, external nares, and/or oral cavity in all rabbits receiving each treatment. The intranasal distribution volumes of the contrast medium were 287 (250-333) mm |
| Databáze: | OpenAIRE |
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