Roles of maltodextrin and inulin as matrix formers on particle performance of inhalable drug nanocrystal-embedded microparticles
| Autor: | Yueqin Ma, Huaping Yu, Guiting Huang, Qin Zheng, Pengfei Yue, Zeng-Zhu Zhang, Yijing Luo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Water activity Surface Properties Organic Chemistry Inulin 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Maltodextrin 01 natural sciences 0104 chemical sciences Matrix (chemical analysis) chemistry.chemical_compound Chemical engineering chemistry Nanocrystal Polysaccharides Administration Inhalation Glassy matrix Materials Chemistry Nanoparticles Particle Particle Size 0210 nano-technology |
| Zdroj: | Carbohydrate Polymers. 235:115937 |
| ISSN: | 0144-8617 |
| Popis: | The objective of this study was to investigate the influence of inulin (IL) and maltodextrin (MD) as matrix formers on the physical properties of drug nanocrystal-embedded microparticles (NEM) during spray-drying and storage. The redispersibility, aerodynamic performance and phase behaviour of NEM/MD and NEM/IL stored at different water activity (aw) values were evaluated. NEM with 2 g/g (relative to the weight of drug) of IL and MD exhibited the excellent performance after spray-drying. The water activity significantly influenced the redispersibility and aerodynamic performance of NEM/MD and NEM/IL. The NEM/MD presented a higher Tg at all aw values than did NEM/IL. The moisture-induced collapse of the amorphous glassy matrix of IL and MD could be responsible for the poor redispersibility and aerodynamic performance of NEM/IL and NEM/MD, respectively. The NEM/MD exhibited better aerodynamic performance at high aw (0.528) than did NEM/IL. Therefore, MD could be an excellent matrix former for inhalable NEM. |
| Databáze: | OpenAIRE |
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