Assessment of local and systemic 25-hydroxy-vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis
| Autor: | Ahmet Inanir, Osman Demir, Ozge Gokturk, Humeyra Aydemir Turkal, Hatice Balci Yuce, İsmail Benli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine rheumatoid arthritis medicine.medical_specialty vitamin D Gastroenterology Proinflammatory cytokine Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Humans Vitamin D Periodontitis Receptor RANKL/OPG General Dentistry biology Tumor Necrosis Factor-alpha business.industry RANK Ligand Osteoprotegerin chronic periodontitis Gingival Crevicular Fluid 030206 dentistry Middle Aged medicine.disease Chronic periodontitis 030104 developmental biology RANKL Case-Control Studies Rheumatoid arthritis biology.protein Female Tumor necrosis factor alpha business |
| Popis: | WOS:000411046800012 PubMed: 28904316 The present study aimed to evaluate proinflammatory cytokine and vitamin D levels in rheumatoid arthritis (RA) and chronic periodontitis (CP) patients and healthy individuals before and after initial periodontal treatment. Overall, 17 CP patients with RA (RA + CP), 18 systemically healthy CP patients (CP), and 18 healthy controls (C) were included. Clinical periodontal measurements were recorded and gingival crevicular fluid (GCF) and blood samples were recorded. RA + CP and CP patients received nonsurgical periodontal treatment. Vitamin D, tumor necrosis factor (TNF)-alpha, receptor activator of nuclear factor-KB ligand (RANKL), and OPG levels were determined in GCF and serum. Baseline clinical parameters were similar in all periodontitis groups (F>0.05) but were higher than that in controls (P < 0.05). Periodontal treatment improved clinical parameters in all periodontitis groups (P < 0.05). GCF vitamin D levels were higher in RA + CP and CP groups than in healthy controls, but these levels decreased in the RA + CP group after periodontal treatment (P < 0.05). Serum RANKL and GCF TNF-alpha levels in RA patients decreased after periodontal treatment (P < 0.05). Within the limitations of this study, the results suggested that GCF vitamin D levels are increased in RA patients and decrease after periodontal treatment; therefore, local vitamin D levels might be an important indicator of periodontal bone loss. |
| Databáze: | OpenAIRE |
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