The use of dynamic susceptibility contrast (DSC) MRI to automatically classify patients with first episode psychosis
Autor: | Roberto Cerini, Cinzia Perlini, Gianluca Rambaldelli, Antonio Lasalvia, Umberto Castellani, Mirella Ruggeri, Sarah Tosato, F. Spagnolli, Denis Peruzzo, Veronica Marinelli, Katia De Santi, Paolo Brambilla, Marcella Bellani, Letizia Squarcina |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Adult
Male medicine.medical_specialty Psychosis Support Vector Machine Adolescent SVM Hemodynamics Gadolinium Perfusion scanning Neuropsychological Tests Machine learning Perfusion SVM Young Adult Internal medicine Image Interpretation Computer-Assisted Machine learning medicine Humans Biological Psychiatry Brain Mapping medicine.diagnostic_test Magnetic resonance imaging Blood flow Middle Aged medicine.disease Magnetic Resonance Imaging Perfusion Psychiatry and Mental health Psychotic Disorders Cerebral blood flow Case-Control Studies Cerebrovascular Circulation Cardiology Female Psychology Insula Neuroscience |
Popis: | Hemodynamic changes in the brain have been reported in major psychosis in respect to healthy controls, and could unveil the basis of structural brain modifications happening in patients. The study of first episode psychosis is of particular interest because the confounding role of chronicity and medication can be excluded. The aim of this work is to automatically discriminate first episode psychosis patients and normal controls on the basis of brain perfusion employing a support vector machine (SVM) classifier. 35 normal controls and 35 first episode psychosis underwent dynamic susceptibility contrast magnetic resonance imaging, and cerebral blood flow and volume, along with mean transit time were obtained. We investigated their behavior in the whole brain and in selected regions of interest, in particular the left and right frontal, parietal, temporal and occipital lobes, insula, caudate and cerebellum. The distribution of values of perfusion indexes were used as features in a support vector machine classifier. Mean values of blood flow and volume were slightly lower in patients, and the difference reached statistical significance in the right caudate, left and right frontal lobes, and in left cerebellum. Linear SVM reached an accuracy of 83% in the classification of patients and normal controls, with the highest accuracy associated with the right frontal lobe and left parietal lobe. In conclusion, we found evidence that brain perfusion could be used as a potential marker to classify patients with psychosis, who show reduced blood flow and volume in respect to normal controls. |
Databáze: | OpenAIRE |
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