Cichorium intybus attenuates streptozotocin induced diabetic cardiomyopathy via inhibition of oxidative stress and inflammatory response in rats
| Autor: | Manju Sharma, Aiman Afaque, Mohd Faiyaz Khan, Mohd Ibrahim Khan, Shridhar Dwivedi, Zeeba S Jairajpuri, Danish Ahmed, Yasmeen Shamsi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Thiobarbituric acid
Health Toxicology and Mutagenesis Pharmacology Toxicology medicine.disease_cause streptozotocin 01 natural sciences Lipid peroxidation Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound RA1190-1270 Lactate dehydrogenase diabetic cardiomyopathy TBARS medicine cichorium intybus 030304 developmental biology 0303 health sciences biology food and beverages Glutathione Streptozotocin 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Toxicology. Poisons biology.protein Original Article Oxidative stress medicine.drug |
| Zdroj: | Interdisciplinary Toxicology, Vol 12, Iss 3, Pp 111-119 (2019) Interdisciplinary Toxicology |
| ISSN: | 1337-9569 |
| DOI: | 10.2478/intox-2019-0013 |
| Popis: | The aim of the present study was to investigate the effects of Cichorium intybus on lipid peroxidation activities of both enzymatic and non-enzymatic antioxidants, inflammatory mediators, myocardial enzymes and histopathology of cardiac tissues in experimental diabetic cardiomyopathy (DCM). DCM was induced by single intraperitoneal injection of streptozotocin (STZ) (40 mg/kg) combined with high energy intake in rats. Seed extract of Cichorium intybus (CIE) (250 mg/kg & 500 mg/kg) was administered orally once a day for 3 weeks. Phytochemical investigations of seed extract revealed presence of some active ingredients such as alkaloids, tannins, saponin, phenols, glycosides, steroids, terpenoids and flavonoids. Seed extract of Cichorium intybus confirmed a significant potency towards restoring the blood glucose, an elevation of the levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), blood glutathione (GSH), TNF-α and IL-6 and a reduction in the levels of catalase (CAT) was observed following the STZ treatment. Oxidative stress was accompanied by myocardial degeneration as evidenced by histopathological examination of cardiac tissues. Administration of CIE reduced the lipid peroxides level in heart. Serum levels of AST, GSH, LDH and SOD were brought down to physiological levels by CIE in STZ induced DCM rats. CIE also markedly down-regulated serum TNF-α and IL-6 levels. Catalase that was reduced in serum was brought back to near normal level. The extensive necrotic changes of cardiac tissue by STZ was minimized to normal morphology upon CIE administration. The study demonstrates the cardioprotective effect of CIE via inhibition of oxidative stress and pro-inflammatory cytokines. |
| Databáze: | OpenAIRE |
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