Survival, Intestinal Mucosa Adhesion, and Immunomodulatory Potential of Lactobacillus plantarum Strains
| Autor: | Effie Tsakalidou, Chrysoula C. Tassou, Eleni Mavrogonatou, Petros Ypsilantis, Yiannis Kourkoutas, Georgia Zoumpopoulou, Constantinos Simopoulos, Valentini Santarmaki, Mikis Kiourtzidis, Nikos Chorianopoulos |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Immunoglobulin A Time Factors 030106 microbiology Polymerase Chain Reaction Applied Microbiology and Biotechnology Microbiology Bacterial Adhesion Immunoglobulin G Feces 03 medical and health sciences Immune system Intestinal mucosa Intestine Small medicine Animals Immunologic Factors Large intestine Intestine Large Intestinal Mucosa Microbial Viability biology Probiotics food and beverages General Medicine biology.organism_classification Antibodies Bacterial Small intestine Rats 030104 developmental biology medicine.anatomical_structure Immunoglobulin M biology.protein Lactobacillus plantarum |
| Zdroj: | Current Microbiology. 74:1061-1067 |
| ISSN: | 1432-0991 0343-8651 |
| DOI: | 10.1007/s00284-017-1285-z |
| Popis: | Survival during transit through the gastrointestinal track, intestinal mucosa adhesion, and a potential immunomodulatory effect of Lactobacillus plantarum strains 2035 and ACA-DC 2640 were investigated in a rat model. According to microbiological and multiplex PCR analysis, both strains were detected in feces 24 h after either single-dose or daily administration for 7 days. Intestinal mucosa adhesion of L. plantarum 2035 was noted in the large intestine at 24 h after single-dose administration, while it was not detected at 48 h. Daily dosing, prolonged detection of the strain up to 48 h post-administration, and expanded adhesion to the small intestine. Adhesion of L. plantarum ACA-DC 2640 to the intestinal mucosa after single-dose administration was prolonged and more extended compared to L. plantarum 2035. Daily dosing increased both the levels and the rate of positive cultures of the strains compared to those of the single-dose scheme. In addition, both strains increased total IgG while decreased IgM and IgA serum levels. In conclusion, L. plantarum 2035 and L. plantarum ACA-DC 2640 survived transit through the gastrointestinal track, exhibited transient distinct adhesion to the intestinal mucosa and modulated the systemic immune response. |
| Databáze: | OpenAIRE |
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