Modifications induced by gestational hypertension on platelet calcium transport
| Autor: | Laura Mazzanti, Cester N, Tranquilli Al, A. M. Cugini, Rosa Anna Rabini, C. Romanini, Herbert Valensise |
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| Rok vydání: | 1991 |
| Předmět: |
Gestational hypertension
Blood Platelets medicine.medical_specialty Membrane Fluidity Clinical Biochemistry Pregnancy Complications Cardiovascular Phospholipid chemistry.chemical_element Biological Transport Active Calcium-Transporting ATPases Calcium Essential hypertension Calcium in biology Pathology and Forensic Medicine chemistry.chemical_compound Membrane Lipids Cytosol Pregnancy Reference Values Internal medicine Membrane fluidity medicine Humans Molecular Biology Phospholipids Chemistry Cholesterol Cell Membrane medicine.disease Endocrinology Hypertension Female Sodium-Potassium-Exchanging ATPase Intracellular |
| Zdroj: | Experimental and molecular pathology. 54(2) |
| ISSN: | 0014-4800 |
| Popis: | Several studies have recently demonstrated that the platelets of subjects affected by essential hypertension have, in their basal state, an elevated cellular calcium content. Such data appear particularly interesting with regard to gestational hypertension (GH). Supposing that the intracellular calcium may be involved in the regulation of blood pressure we have studied the cytosolic calcium concentration, Na+/K(+)-ATPase activity, Ca(2+)-ATPase activity, fluidity, and the cholesterol/phospholipid (C/P) molar ratio of the plasma membranes in platelets from 20 normotensive pregnant women and 20 women affected by mild gestational hypertension without pharmacological treatment, near term. We observed an increased Ca(2+)-ATPase activity and a decreased Na(+)K(+)-ATPase activity in GH compared to the controls, accompanied by an increased Ca2+ intraplatelet concentration in the same patients. The fluidity and the C/P molar ratio were also increased. Our study gives indirect support to the hypothesis, supposing a reduced Na+/K(+)-ATPase activity which might cause increased intracellular Na+ content and decreased Ca2+ efflux through the Na+/Ca2+ exchange. However, out data can not rule out the other hypotheses explaining the increased cellular Ca2+ content. The present data indicate that GH is accompanied by a membrane structural abnormality that alters its physical state and modifies the membrane-related cellular functions. |
| Databáze: | OpenAIRE |
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