Apolipoprotein E (APOE), PARKIN and catechol-O-methyltransferase (COMT) genes and susceptibility to sporadic Parkinson's disease in Finland
| Autor: | Jyrki Launes, Pentti J. Tienari, J. Eerola, O. Hellström |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Apolipoprotein E Candidate gene Parkinson's disease Genotype Ubiquitin-Protein Ligases Single-nucleotide polymorphism Biology Catechol O-Methyltransferase Parkin Ligases Apolipoproteins E medicine Humans Genetic Predisposition to Disease Allele Finland Aged Aged 80 and over Genetics Polymorphism Genetic Catechol-O-methyl transferase General Neuroscience Parkinson Disease Middle Aged medicine.disease nervous system diseases Genotype frequency Female |
| Zdroj: | Neuroscience Letters. 330:296-298 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(02)00819-4 |
| Popis: | Recent studies have demonstrated that genetic factors modify susceptibility to sporadic Parkinson's disease (PD). So far the results of candidate gene studies have been conflicting. It has been suggested that polymorphisms in apolipoprotein E (APOE), PARKIN and catechol-O-methyltransferase (COMT) genes might increase the risk of PD. We studied 147 Finnish non-demented patients with sporadic PD and 137 controls. APOE ϵ allele and genotype frequencies in PD patients did not differ significantly from controls. Three single nucleotide polymorphisms of the PARKIN gene and an intronic and an exonic (Val158Met) polymorphism of the COMT gene were studied. None of these polymorphisms showed association with PD in our series. In contrast to reports in oriental populations, our results do not support a major role of APOE, PARKIN and COMT polymorphisms in PD susceptibility in the Finnish population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect