Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years
| Autor: | Min Li, Karen Siu-Ling Lam, Tai Hing Lam, Lawrence S. C. Law, Kerry-Anne Rye, Kwok Leung Ong, A Xu, Nelson M.S. Wat, Bernard M.Y. Cheung, A. W. K. Tso |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Combined use 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Biology Gastroenterology Article C-reactive protein 03 medical and health sciences 0302 clinical medicine Sex Factors Sex factors Internal medicine Glucose Intolerance Internal Medicine medicine Humans Prospective Studies 10. No inequality Prospective cohort study Proportional Hazards Models Adiponectin Proportional hazards model nutritional and metabolic diseases Human physiology Biomarker Middle Aged 3. Good health Endocrinology biology.protein Biomarker (medicine) Female Glycaemia hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | Diabetologia |
| ISSN: | 1432-0428 0012-186X |
| Popis: | Aims/hypothesis: Hypoadiponectinaemia and raised C-reactive protein (CRP) level are obesity-related biomarkers associated with glucose dysregulation. We evaluated the combined use of these two biomarkers in predicting the deterioration of glycaemia in a prospective study after a median of 5.4 years. Methods: In total 1,288 non-diabetic participants from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, with high-sensitivity CRP (hsCRP) and total adiponectin levels measured were included. OGTT was performed in all participants. Two hundred and six participants had deterioration of glycaemia at follow-up, whereas 1,082 participants did not. Results: Baseline age, hsCRP and adiponectin levels were significant independent predictors of the deterioration of glycaemia in a Cox regression analysis after adjusting for baseline age, sex, BMI, hypertension, triacylglycerols, 2 h post-OGTT glucose and homeostasis model assessment of insulin resistance index (all p < 0.01). The introduction of hsCRP or adiponectin level to a regression model including the other biomarker improved the prediction of glycaemic progression significantly in all participants, especially in women (all p < 0.01). The combined inclusion of the two biomarkers resulted in a modest improvement in model discrimination, compared with the inclusion of either one alone. Among participants with impaired fasting glucose/impaired glucose tolerance (IFG/IGT) at baseline, hsCRP and adiponectin levels were not predictive of progression or improvement of glycaemic status. Conclusions/interpretation: Adiponectin and hsCRP levels are independent factors in predicting the deterioration of glycaemia, supporting the role of adiposity-related inflammation in the development of type 2 diabetes. Their combined use as predictive biomarkers is especially useful in women, but not in participants with IFG/IGT. © 2011 The Author(s). published_or_final_version Springer Open Choice, 21 Feb 2012 |
| Databáze: | OpenAIRE |
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