Biomaterial-Guided Recombinant Adeno-associated Virus Delivery from Poly(Sodium Styrene Sulfonate)-Grafted Poly(ɛ-Caprolactone) Films to Target Human Bone Marrow Aspirates

Autor:	Véronique Migonney, Amélie Leroux, Jagadeesh K. Venkatesan, Céline Falentin-Daudré, Magali Cucchiarini
Rok vydání:	2019
Předmět:	Sodium Polyesters 0206 medical engineering Genetic Vectors Biomedical Engineering chemistry.chemical_element Bioengineering Biocompatible Materials 02 engineering and technology medicine.disease_cause Biochemistry Styrene law.invention Biomaterials 03 medical and health sciences chemistry.chemical_compound law Transduction Genetic medicine Humans Adeno-associated virus 030304 developmental biology 0303 health sciences Gene Transfer Techniques Biomaterial Dependovirus 020601 biomedical engineering Molecular biology Sulfonate medicine.anatomical_structure chemistry Recombinant DNA Poly ɛ caprolactone Bone marrow Chondrogenesis
Zdroj:	Tissue engineering. Part A. 26(7-8)
ISSN:	1937-335X
Popis:	Scaffold-guided gene transfer offers strong systems to develop noninvasive convenient therapeutic options for the treatment of articular cartilage defects, especially when targeting bone marrow aspirates from patients containing chondroregenerative mesenchymal stromal cells in a native microenvironment. In this study, we examined the feasibility of delivering reporter (red fluorescent protein [RFP]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0cc4e5e6576c1e176c91f595f085ce https://pubmed.ncbi.nlm.nih.gov/31680637 Zobrazit plný text záznamu