Maternal prenatal urinary bisphenol A level and child cardio-metabolic risk factors: A prospective cohort study

Autor: Kun Du, Xia Wang, Xiaobin Wang, Fengxiu Ouyang, Guang-Hui Zhang, Li-xiao Shen, Rui Ma, Jun Zhang
Rok vydání: 2020
Předmět:
Zdroj: Environmental Pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Popis: Exposure to endocrine disrupting chemicals during the first 1000 days of life may have long-lasting adverse effects on cardio-metabolic risk in later life. This study aimed to examine the associations between maternal prenatal Bisphenol A (BPA) exposure and child cardio-metabolic risk factors at age 2 years in a prospective cohort. During 2012–2013, 218 pregnant women were enrolled at late pregnancy from Shanghai, China. Urinary BPA concentration was measured in prenatal and child 2-year spot urine samples, and classified into high, medium and low tertiles. Child adiposity anthropometric measurements, random morning plasma glucose, serum insulin, and lipids (high-density lipoprotein, low-density lipoprotein, cholesterol, triglyceride), systolic (SBP) and diastolic blood pressure (DBP) were measured. Linear regression was used to evaluate the associations between prenatal BPA and each of the cardio-metabolic risk factors in boys and girls, respectively, adjusting for pertinent prenatal, perinatal and postnatal factors. BPA was detectable (>0.1 μg/L) in 98.2% of mothers prenatally and 99.4% of children at age 2 years. Compared to those with low prenatal BPA, mean SBP was 7.0 (95%CI: 2.9–11.2) mmHg higher, and DBP was 4.4 (95%CI: 1.2–7.5) mmHg higher in girls with high prenatal BPA levels, but these associations were not found in boys. In boys, medium maternal prenatal BPA level was associated with 0.36 (95% CI: 0.04–0.68) mmol/L higher plasma glucose. No associations were found between prenatal BPA and child BMI, skinfold thicknesses, serum lipids, or insulin in either girls or boys. There were no associations between concurrent child urinary BPA and cardio-metabolic risk factors. These results support that BPA exposure during prenatal period, susceptible time for fetal development, may be associated with increase in child BP and plasma glucose in a sex-specific manner. Further independent cohort studies are needed to confirm the findings.
Graphical abstract Image 1
Highlights • Maternal prenatal BPA was associated sex-specifically with child blood pressure. • Prenatal BPA was associated with higher blood pressure in girls at 2 years. • Medium prenatal BPA was associated with higher plasma glucose in boys. • No associations between concurrent child BPA and cardio-metabolic risk factors.
Databáze: OpenAIRE
Externí odkaz: