Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk of Developing Breast Cancer and Clinical Pathologic Features
| Autor: | Renato Salerno Wilkens, Bibiana Sgorla de Almeida, Leili Daiane Hausmann, Daniella Serafin Couto Vieira, Guilherme de Toledo e Silva, Ilíada Rainha de Souza, Manuela Nunes Drehmer, Bráulio Leal Fernandes, Yara Costa Netto Muniz, Sara Emelie Löfgren, Juliana Dal-Ri Lindenau |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty Genotype Breast Neoplasms Disease Biology Lower risk Polymorphism Single Nucleotide Biochemistry 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Polymorphism (computer science) Internal medicine Progesterone receptor Biomarkers Tumor Genetics medicine Humans Genetic Predisposition to Disease Allele Molecular Biology Ecology Evolution Behavior and Systematics Aged Receptors Interferon Aged 80 and over General Medicine Middle Aged Prognosis medicine.disease SNP genotyping Gene Expression Regulation Neoplastic 030104 developmental biology Receptors Tumor Necrosis Factor Type I Case-Control Studies 030220 oncology & carcinogenesis Female Brazil Follow-Up Studies |
| Zdroj: | Biochemical Genetics. 59:1233-1246 |
| ISSN: | 1573-4927 0006-2928 |
| Popis: | Several genes have been associated with breast cancer (BC) susceptibility. The tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), and interferon lambda receptor 1 (IFNLR1) genes encode receptors that mediate the action of inflammatory cytokines. Previous studies have demonstrated the association of the variants rs1800693 (TNFRSF1A) and rs4649203 (IFNLR1) with some inflammatory diseases. The present study aimed to verify a possible association of these variants with BC, its clinical pathologic features, as well as epidemiological data in a Brazilian population. A total of 243 patients and 294 individuals without history of BC were genotyped for these polymorphisms through TaqMan® SNP genotyping assays by qPCR. For the TNFRSF1A gene, no significant results were found. For IFNLR1, the AA genotype (p = 0.008) and the A allele (p = 0.02) were significantly associated with a lower risk of developing BC. When analyzing the age, it was observed that each increase of one year contributes to the development of BC (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink