Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers
| Autor: | Gabriella Cadoni, Aida Ferreiro-Iglesias, Neil C Caporaso, Stig E. Bojesen, Mark C. Weissler, Stefania Boccia, Christopher I. Amos, Hans Brunnström, Maria Teresa Landi, Ma'en Obeidat, Corina Lesseur, James McKay, Heike Bickeböller, Shanbeh Zienolddiny, Andy R Ness, Steve Thomas, Adonina Tardón, Angela Risch, Rayjean J. Hung, Chu Chen, Valerie Gaborieau, Richard S. Houlston, Andrew F. Olshan, Gary M. Clifford, Lambertus A. Kiemeney, Brenda Diergaarde, Eloiza H. Tajara, Mattias Johansson, Stephen Lam, Demetrios Albanes, Melinda C. Aldrich, Martin Lacko, Olle Melander, Wim Timens, Angeline S. Andrew, Robert L. Ferris, Victor Wünsch-Filho, John K. Field, Xiangjun Xiao, Loic Le Marchand, Philip Lazarus, Kjell Grankvist, M.D. Teare, Yohan Bossé, Geoffrey Liu, Matthew B. Schabath, Gadi Rennert, Paul Brennan, Sanjay Shete, Liloglou Triantafillos, Susanne M. Arnold, David C. Christiani, Mikael Johansson |
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| Přispěvatelé: | RS: GROW - R2 - Basic and Translational Cancer Biology, MUMC+: MA Keel Neus Oorheelkunde (9), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Research Institute for Asthma and COPD (GRIAC) |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Epidemiology Genome-wide association study QH426-470 VARIANTS Digestive System Neoplasms Lung and Intrathoracic Tumors head and neck Mathematical and Statistical Techniques 0302 clinical medicine Pleiotropy Breast Tumors Odds Ratio Medicine and Health Sciences PROSTATE NETWORK Genetics (clinical) Genetics 0303 health sciences Cancer Risk Factors Statistics ADH1B Genomics Metaanalysis 3. Good health Oncology Aerodigestive Tract 030220 oncology & carcinogenesis Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] Physical Sciences Carcinoma Squamous Cell Settore MED/31 - OTORINOLARINGOIATRIA Anatomy Larynx Medical Genetics Signal Transduction Research Article Genotype Esophageal Cancer CARCINOMA SUSCEPTIBILITY LOCI Biology Research and Analysis Methods Throat 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center LUNG-CANCER Gastrointestinal Tumors Breast Cancer Biomarkers Tumor Genome-Wide Association Studies Genetic predisposition medicine Humans BREAST-CANCER Genetic Predisposition to Disease Epigenetics Statistical Methods Lung cancer Molecular Biology Gene Ecology Evolution Behavior and Systematics Medicinsk genetik 030304 developmental biology MUTATIONS Cancers and Neoplasms Biology and Life Sciences Computational Biology Human Genetics ALLELES Genome Analysis medicine.disease BRCA2 Genetic Loci Medical Risk Factors Mathematics Neck Genome-Wide Association Study |
| Zdroj: | Scopus RUO. Repositorio Institucional de la Universidad de Oviedo instname Plos Genetics, 17, 3 Plos Genetics, 17 Plos Genetics, 17(3):e1009254. Public Library of Science PLoS Genetics Lesseur, C, Ferreiro-Iglesias, A, McKay, J D, Bossé, Y, Johansson, M, Gaborieau, V, Landi, M T, Christiani, D C, Caporaso, N C, Bojesen, S E, Amos, C I, Shete, S, Liu, G, Rennert, G, Albanes, D, Aldrich, M C, Tardon, A, Chen, C, Triantafillos, L, Field, J K, Teare, M D, Kiemeney, L A, Diergaarde, B, Ferris, R L, Zienolddiny, S, Lam, S, Olshan, A F, Weissler, M C, Lacko, M, Risch, A, Bickeböller, H, Ness, A R, Thomas, S, Le Marchand, L, Schabath, M B, Wünsch-Filho, V, Tajara, E H, Andrew, A S, Clifford, G M, Lazarus, P, Grankvist, K, Johansson, M, Arnold, S, Melander, O, Brunnström, H, Boccia, S, Cadoni, G, Timens, W, Obeidat, M, Xiao, X, Houlston, R S, Hung, R J & Brennan, P 2021, ' Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers ', PLOS Genetics, vol. 17, no. 3, e1009254, pp. 1-19 . https://doi.org/10.1371/journal.pgen.1009254 PLoS Genetics, Vol 17, Iss 3, p e1009254 (2021) Lesseur, C, Ferreiro-Iglesias, A, McKay, J D, Bossé, Y, Johansson, M, Gaborieau, V, Landi, M T, Christiani, D C, Caporaso, N C, Bojesen, S E, Amos, C I, Shete, S, Liu, G, Rennert, G, Albanes, D, Aldrich, M C, Tardon, A, Chen, C, Triantafillos, L, Field, J K, Teare, M D, Kiemeney, L A, Diergaarde, B, Ferris, R L, Zienolddiny, S, Lam, S, Olshan, A F, Weissler, M C, Lacko, M, Risch, A, Bickeböller, H, Ness, A R, Thomas, S, Le Marchand, L, Schabath, M B, Wünsch-Filho, V, Tajara, E H, Andrew, A S, Clifford, G M, Lazarus, P, Grankvist, K, Johansson, M, Arnold, S, Melander, O, Brunnström, H, Boccia, S, Cadoni, G, Timens, W, Obeidat, M, Xiao, X, Houlston, R S, Hung, R J & Brennan, P 2021, ' Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers ', PLoS Genetics, vol. 17, no. 3, e1009254 . https://doi.org/10.1371/journal.pgen.1009254 PLoS genetics, 17(3):e1009254. PUBLIC LIBRARY SCIENCE |
| ISSN: | 1553-7404 1553-7390 |
| DOI: | 10.1371/journal.pgen.1009254 |
| Popis: | Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta Author summary Squamous cell carcinomas are specific type of cancer that can arise in multiple organs of the aerodigestive tract including the lung, oral cavity, oropharynx, larynx and esophagus. Previous studies have shown that aerodigestive squamous cell carcinomas share common environmental risk factors (tobacco smoking and alcohol intake). Here, we investigate genetic factors involved in the risk of aerodigestive squamous cell carcinomas as a group in a large genetic association study involving 13,887 cancer cases and 61,961 controls. We identified one genome-wide significant region within 2q33.1 and 3 other suggestive regions at 1q32.1, 5q31.2 and 19p13.11. Gene-based analyses also identify a list of SqCC-related genes that are involved in DNA damage response and epigenetic regulation. Our results suggest some overlap in the genetic factors influencing the risk of aerodigestive squamous cell carcinomas in European populations and highlights the importance of cross-cancer studies. |
| Databáze: | OpenAIRE |
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