A mini library of novel triazolothiadiazepinylindole analogues: synthesis, antioxidant and antimicrobial evaluations
| Autor: | Naveen Jaiprakash Biradar, Sasidhar B. Somappa, J. S. Biradar, Parveen Rajesab |
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| Rok vydání: | 2013 |
| Předmět: |
Antioxidant
Article Subject medicine.medical_treatment Proton Magnetic Resonance Spectroscopy lcsh:Medicine lcsh:Technology General Biochemistry Genetics and Molecular Biology Antioxidants Mass Spectrometry Anti-Infective Agents Spectroscopy Fourier Transform Infrared medicine Organic chemistry Potency Carbon-13 Magnetic Resonance Spectroscopy lcsh:Science General Environmental Science Free Radical Scavenging Activity lcsh:T Chemistry lcsh:R General Medicine Triazoles Antimicrobial Antioxidant capacity Proton NMR Ferric lcsh:Q medicine.drug Research Article |
| Zdroj: | The Scientific World Journal The Scientific World Journal, Vol 2014 (2014) |
| ISSN: | 1537-744X |
| Popis: | A new series of novel triazolothiadiazepinylindole analogues were synthesized with an aim to examine possible antioxidant and antimicrobial activities. The titled compounds (3a–z) were obtained in good yield by reacting 5-(5-substituted-3-phenyl-1H-indol-2-yl)-4-amino-4H-1,2,4-triazole-3-thiols1a–cwith 3-(2,5-disubstituted-1H-indol-3-yl)-1(4-substituted phenyl)prop-2-en-1-ones2a–i. All the newly synthesized compounds were characterized by IR,1H NMR, mass spectroscopic and analytical data. The synthesized analogues were tested for antioxidant and antimicrobial potency. Among the tested compounds3a–cand3j–lhave shown very promising free radical scavenging activity and total antioxidant capacity. Compounds3d–f,3m–o, and3s–zhave shown excellent ferric reducing antioxidant activity. An outstanding antimicrobial activity is observed with compounds3a–cand3j–l. |
| Databáze: | OpenAIRE |
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