Sex differences in nuclear receptor-regulated liver metabolic pathways
| Autor: | Walter Wahli, Gianpaolo Rando |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Nuclear receptor crosstalk
Male medicine.medical_specialty Peroxisome proliferator-activated receptor Gender dimorphism Disease Biology Retinoid X receptor Liver sex dimorphism 03 medical and health sciences 0302 clinical medicine Sex Factors Sexual differences Nuclear receptors Internal medicine medicine Animals Humans Liver X receptor Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Pregnane X receptor Sexual dimorphism Endocrinology chemistry Nuclear receptor Liver 030220 oncology & carcinogenesis Molecular Medicine Female Hormone |
| Zdroj: | Biochimica et biophysica acta |
| ISSN: | 0006-3002 |
| Popis: | Liver metabolism is markedly sex-dimorphic; accordingly, the prevalence of liver diseases is different between sexes. The superfamily of nuclear receptors (NRs) governs the proper expression of key liver metabolism genes by sensing lipid-soluble hormones and dietary lipids. When the expression of those genes is deregulated, disease development is favored. However, we lack a comprehensive picture of the differences between NR actions in males and females. Here, we reviewed explorative studies that assessed NR functions in both sexes, and we propose a first map of sex-dimorphic NR expression in the liver. Our analysis suggested that NRs in the female liver exhibited cross-talk with more liver-protective potential than NRs in male liver. This study provides empirical support to the hypothesis that women are more resilient to some liver diseases than men, based on a more compensative NR network. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease. |
| Databáze: | OpenAIRE |
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