Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure
| Autor: | Carlo Alessandria, Carmine Gambino, Javier Fernández, Hans Van Vlierberghe, Sophie Restellini, Marcos Girala, Luis Colombato, Tae Hee Lee, Nikolaos Pyrsopoulos, Eduardo Fassio, Sang Gyune Kim, Gisela Pinero, Paolo Caraceni, Shivaram Prasad Singh, Do Seon Song, Ji Won Park, Julio Vorobioff, Dong Joon Kim, C. Toledo, Aleksander Krag, Liane Rabinowich, Preetam Nath, Robert A. de Man, Elza Cotrim Soares, Xavier Verhelst, Tiago Sevá Pereira, Gustavo Romero, Macarena Simón-Talero, Sung Eun Kim, Michele Bartoletti, Alexander L. Gerbes, Sebastián Marciano, Tony Bruns, Hyoung Su Kim, Ki Tae Suk, Nicolas M. Intagliata, Annette Dam Fialla, Adrià Juanola, Manuela Merli, Rita de Cassia Ribeiro Barea, Laure Elkrief, Rakhi Maiwall, Laurentius A Lesmana, Pere Ginès, Vikas Gautam, E.L. Yoon, M. Marino, Paolo Angeli, Kalyan Ram Bhamidimarri, Victor Vargas, Virendra Singh, Juan Pablo Roblero, François Durand, Cosmas A. Rinaldi Lesmana, M. V. Maevskaya, Gustavo Navarro, Adrian Gadano, Florence Wong, Pramod Kumar, Tae Hun Kim, Daniela Campion, Salvatore Piano, Giacomo Zaccherini, Barbara Lattanz, Jae Seok Hwang, Sun Young Yim, Thomas D. Boyer, Jeong Han Kim, Carlos Brodersen |
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| Přispěvatelé: | Wong F., Piano S., Singh V., Bartoletti M., Maiwall R., Alessandria C., Fernandez J., Soares E.C., Kim D.J., Kim S.E., Marino M., Vorobioff J., Barea R.D.C.R., Merli M., Elkrief L., Vargas V., Krag A., Singh S.P., Lesmana L.A., Toledo C., Marciano S., Verhelst X., Intagliata N., Rabinowich L., Colombato L., Kim S.G., Gerbes A., Durand F., Roblero J.P., Bruns T., Yoon E.L., Girala M., Pyrsopoulos N.T., Kim T.H., Yim S.Y., Juanola A., Gadano A., Angeli P., Bhamidimarri K., Boyer T.D., Brodersen C., Campion D., Caraceni P., de Man R.A., Fassio E., Fialla A.D., Gambino C., Gautam V., Gines P., Hwang J.S., Kim H.S., Kim J.H., Kumar P., Lattanz B., Lee T.H., Rinaldi Lesmana C.A., Maevskaya M., Nath P., Navarro G., Park J.-W., Pinero G., Restellini S., Romero G., Seva -Pereira T., Simon-Talero M., Song D.S., Suk K.T., Van Vlierberghe H., Zaccherini G. |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Cirrhosis Organ Dysfunction Scores Antibiotic resistance medicine.medical_treatment Liver transplantation Severity of Illness Index 0302 clinical medicine ACLF MDR Epidemiology Cross Infection Mortality rate Age Factors Bacterial Infections Middle Aged Prognosis Community-Acquired Infections Europe Hospitalization Female 030211 gastroenterology & hepatology Alcohol-Related Disorders medicine.medical_specialty Sepsi India Risk Assessment Sepsis 03 medical and health sciences Sex Factors Spontaneous bacterial peritonitis Internal medicine medicine Humans XDR Cirrhosi Hepatology business.industry Acute-On-Chronic Liver Failure medicine.disease Pneumonia 030104 developmental biology antibiotic resistance liver transplantation sepsis business |
| Zdroj: | Wong, F, Piano, S, Singh, V, Bartoletti, M, Maiwall, R, Alessandria, C, Fernandez, J, Soares, E C, Kim, D J, Kim, S E, Marino, M, Vorobioff, J, Barea, R D C R, Merli, M, Elkrief, L, Vargas, V, Krag, A, Singh, S P, Lesmana, L A, Toledo, C, Marciano, S, Verhelst, X, Intagliata, N, Rabinowich, L, Colombato, L, Kim, S G, Gerbes, A, Durand, F, Roblero, J P, Bruns, T, Yoon, E L, Girala, M, Pyrsopoulos, N T, Kim, T H, Yim, S Y, Juanola, A, Gadano, A, Angeli, P & on behalf of theInternational Club of Ascites Global Study Group 2021, ' Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure ', Journal of Hepatology, vol. 74, no. 2, pp. 330-339 . https://doi.org/10.1016/j.jhep.2020.07.046 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/j.jhep.2020.07.046 |
| Popis: | Background & Aims: Bacterial infections can trigger the development of organ failure(s) and acute-on-chronic liver failure (ACLF). Geographic variations in bacteriology and clinical practice could lead to worldwide differences in ACLF epidemiology, phenotypes and associated outcomes. Herein, we aimed to evaluate regional differences in bacterial infection-related ACLF in patients with cirrhosis admitted to hospital. Methods: This post hoc analysis included 1,175 patients with decompensated cirrhosis (with bacterial infection on admission or nosocomial infection) from 6 geographic regions worldwide. Clinical, laboratory and microbiological data were collected from the diagnosis of infection. Patients were followed-up for organ failure(s) and ACLF development according to the EASL-CLIF criteria from enrolment to discharge/death. Results: A total of 333 patients (28%) had ACLF at diagnosis of infection, while 230 patients developed ACLF after diagnosis of infection, resulting in an overall rate of bacterial infection related-ACLF of 48%, with rates differing amongst different geographic regions (38% in Southern Europe vs. 75% in the Indian subcontinent). Bacterial infection related-ACLF more frequently developed in younger patients (55 ± 13 vs. 58 ± 14 years), males (73% vs. 62%), patients with alcohol-related cirrhosis (59% vs. 45%) and those with a higher baseline MELD score (25 ± 11 vs. 16 ± 5) (all p |
| Databáze: | OpenAIRE |
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