Association between Alzheimer's disease and bound autochthonous IgM on T cells
| Autor: | Nanette Solvason, Lindy E. Harrell, Tiepu Liu, Richard M. Allman, Sherron H. Kell |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Cellular immunity Cross-sectional study T cell T-Lymphocytes Population Gastroenterology Alzheimer Disease Internal medicine medicine Dementia Humans Lymphocyte Count education Stroke Geriatric Assessment Aged Aged 80 and over education.field_of_study Memory Disorders business.industry T lymphocyte Middle Aged medicine.disease Flow Cytometry Cerebrovascular Disorders medicine.anatomical_structure Cross-Sectional Studies Dementia Multi-Infarct Immunoglobulin M Case-Control Studies Immunology Female Geriatrics and Gerontology Alzheimer's disease business Mental Status Schedule |
| Zdroj: | Journal of the American Geriatrics Society. 44(11) |
| ISSN: | 0002-8614 |
| Popis: | OBJECTIVE: To determine whether there is an association between the number of peripheral T cells binding IgM per total T cell population (%IgM + T cells) and dementia. DESIGN: Cross-sectional study. SETTING: Two inpatient and two outpatient sites at a university medical center. PARTICIPANTS: Fifty-three adults. MEASUREMENTS: Peripheral blood was collected from each individual, and the %IgM + T cells was determined by flow cytometry. The data obtained by medical record chart review were analyzed to determine whether the %IgM + T cells correlated with cognitive diagnoses, demographic variables, medical diagnoses, or prescribed medications. RESULTS: The %IgM + T cells was negatively correlated with MMSE scores (r = -.33, P = .016). There was a significant difference in the mean %IgM + T cells between Alzheimer's disease (AD) and non-AD patients (35.6% ± 30.2% vs 14.6% ± 23.9%, P < .001) but no statistically significant association between the mean %IgM + T cells and age, sex, race, prescribed medications (except gastrointestinal (GI) medications), or medical diagnoses (except stroke). After statistically controlling for GI medications and stroke, AD remained independently associated with the %IgM + T cells (P = .008). CONCLUSIONS: Patients with AD had significantly more of their T cells coated with IgM than did non-AD patients. J Am Geriatr Soc 44:1362–1365, 1996. |
| Databáze: | OpenAIRE |
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