Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists

Autor:	Alexander Pasternak, Paul Mazur, Michael R. Tota, Stephen D. Goble, Lihu Yang, Donna L. Hreniuk, Andrew D. Howard, Reynalda deJesus, Sander G. Mills, Christine C. Chung, Scott D. Feighner
Rok vydání:	2009
Předmět:	Male genetic structures Drug Inverse Agonism Stereochemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Somatotropin-releasing factor Chemical synthesis Cell Line Rats Sprague-Dawley Structure-Activity Relationship Drug Discovery Inverse agonist Animals Humans Obesity Receptor Receptors Ghrelin Molecular Biology Sulfonamides Chemistry digestive oral and skin physiology Organic Chemistry Antagonist Rats Drug Design Benzene derivatives Molecular Medicine Ghrelin Anti-Obesity Agents Enantiomer hormones hormone substitutes and hormone antagonists
Zdroj:	Bioorganicmedicinal chemistry letters. 19(21)
ISSN:	1464-3405
Popis:	This Letter describes optimization of ghrelin receptor antagonists and inverse agonists starting from a screening hit.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfcd1b4cde935121608bb1f09ea58b2 https://pubmed.ncbi.nlm.nih.gov/19767208 Zobrazit plný text záznamu Full Text from ScienceDirect