Superficial cryotherapy using dimethyl ether and propane mixture versus microneedling in the treatment of alopecia areata: A prospective single-blinded randomized clinical trial
| Autor: | Zeinab Abu-Elbaha Gouda, Soha Aboeldahab, Essam A. Nada, Hanan Abdel-Rady Assaf, Mohammed Abu El-Hamd |
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| Rok vydání: | 2021 |
| Předmět: |
Methyl Ethers
Alopecia Areata Photographic documentation business.industry medicine.medical_treatment Cryotherapy Dermatology General Medicine Alopecia areata medicine.disease Therapeutic modalities law.invention Clinical trial Propane medicine.anatomical_structure Randomized controlled trial law Anesthesia Scalp medicine Humans Prospective Studies business |
| Zdroj: | Dermatologic therapyREFERENCES. 34(5) |
| ISSN: | 1529-8019 |
| Popis: | Objective To verify and compare the therapeutic efficacy and safety of superficial cryotherapy using dimethyl ether and propane (DMEP) mixture versus microneedling in the treatment of mild scalp AA. Methods In a prospective randomized single-blinded clinical trial, 80 patients of with clinically evident scalp mild AA were randomly assigned into two groups of 40 patients each. Group (1) was treated by superficial cryotherapy using DMEP in 3 freeze-thaw cycles of 5 seconds each. Group (2) was treated by microneedling. Both groups were treated every 2 weeks for 6 sessions and followed up for 3 months after the last session. Patients were assessed by photographic documentation, trichoscopic evaluations, severity of alopecia tool (SALT) score and alopecia areata symptom impact scale (AASIS). Results An excellent response was achieved in 15 (37.5%) of group 1 compared with 14 (35%) of group (2) patients, while a good response was achieved in 23 (57.5%) of group (1) compared with 21 (52.5%) of group (1) patients, with a statistically insignificant difference. The mean SALT score change percentage was statistically significantly higher in group (2) patients. The mean AASIS change percentage was higher in group (1) patients, but this was statistically insignificant. In both groups, the mean numbers of trichoscopic signs of AA significantly decreased from baseline to the end of follow-up period. Both therapeutic modalities were well-tolerated, with no recurrence after the follow-up period. Conclusion Both superficial cryotherapy using DMEP mixture, and microneedling are simple, effective, and safe therapeutic options for mild scalp AA, however, microneedling showed higher efficacy. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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