Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors
| Autor: | Jon Cartledge, Ian Eardley, Joby Taylor, Omer Baldo, Anne Storey |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Side effect medicine.drug_mechanism_of_action Phosphodiesterase Inhibitors Visual analogue scale Sildenafil Urology Piperazines Sildenafil Citrate Tadalafil chemistry.chemical_compound Erectile Dysfunction Vardenafil Dihydrochloride Surveys and Questionnaires Internal medicine medicine Humans Prospective Studies Sulfones Triazines business.industry Imidazoles Middle Aged medicine.disease Surgery Clinical trial Erectile dysfunction chemistry Patient Satisfaction Purines Vardenafil business Phosphodiesterase 5 inhibitor Carbolines medicine.drug |
| Zdroj: | BJU International. 103:1392-1395 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2008.08328.x |
| Popis: | OBJECTIVE To assess whether the longer half-life of tadalafil is associated with longer lasting or more severe side-effects than the other phosphodiesterase type 5 inhibitors (PDE-5Is), as clinical trials have shown that the efficacy and safety of the three available are similar, but tadalafil has a half-life four times longer than the other two drugs. PATIENTS AND METHODS Treatment-naive men beginning PDE5-I therapy were recruited from a specialist clinic. Data on the type and duration of drug-associated side-effects were collected prospectively. Levels of bother were assessed with a visual analogue scale (VAS). Differences in type, duration and bother of side-effect were compared between drugs. RESULTS In all, 409 men provided data; there were no differences between drugs in the proportion of men responding, or the overall prevalence of side-effects. The mean duration of side-effects with tadalafil was 14.9 h, compared to 3.9 and 7.7 h for sildenafil and vardenafil. Of men taking tadalafil, 30% had side-effects lasting >12 h. There were no differences in mean VAS scores between the drugs. Individual side-effects caused similar levels of bother, except for facial flushing, which was less bothersome. CONCLUSIONS Men taking tadalafil are at risk of prolonged side-effects, although levels of bother associated with these side-effects are not significantly greater than those seen with short-acting PDE5-Is. |
| Databáze: | OpenAIRE |
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