The Associations between Sex Hormones and Lipid Profiles in Serum of Women with Different Phenotypes of Polycystic Ovary Syndrome
| Autor: | Agnieszka Piwowar, Artur Nowak, Malwina Szynkaruk-Matusiak, Justyna Niepsuj, Anna Bizoń, Marta Czwojdzińska, Paweł Madej, Grzegorz Franik, Marcin Leśniewski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Article lipids Sex hormone-binding globulin Internal medicine Hyperlipidemia medicine disorders Testosterone medicine.diagnostic_test biology business.industry Free androgen index phenotypes nutritional and metabolic diseases hormonal status General Medicine Androgen medicine.disease Polycystic ovary Endocrinology polycystic ovary syndrome biology.protein Medicine Lipid profile business Hormone |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 3941, p 3941 (2021) Journal of Clinical Medicine Volume 10 Issue 17 |
| ISSN: | 2077-0383 |
| Popis: | We aimed to evaluate the relationship between selected serum sex hormones and lipid profiles in a group of women with polycystic ovary syndrome (PCOS) dividing according to four phenotypes, value of body mass index (BMI), and presence of hyperlipidemia. The study included 606 Caucasian women. Lipids and selected hormones were estimated using commercially available procedures during hospitalization in 2017. Phenotype of PCOS, BMI value, and hyperlipidemia were significant factors that influenced androgen hormone concentrations, such as total and free testosterone and androstenedione as well as the value of free androgen index (FAI). Moreover, significant changes in concentrations of dehydroepiandrosterone sulphate and sex hormone binding globulin (SHBG) were found between those groups. Higher quartiles of triglyceride concentrations increased the odds ratio of decreased concentrations of SHBG or increased values of FAI, while an adverse relation was found in case of HDL-C. The concentration of estradiol in the blood of women with PCOS was not associated with lipid profile parameters in any investigated groups. Probably, irregularities in sex hormone concentrations during PCOS is not directly associated with lipid profile parameters but could be reflective of the concentration of SHBG or the ratio of SHBG and total testosterone and their association with lipids. |
| Databáze: | OpenAIRE |
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