A longitudinal PRINTO study on growth and puberty in juvenile systemic lupus erythematosus
| Autor: | Sylvie Gandon Laloum, Nicolino Ruperto, Marite Rygg, Chantal Job Deslandre, Rosa Roldan-Molina, Brigitte Bader-Meunier, Katerina Jarosova, Angelo Ravelli, Franco Garofalo, Tsivia Tauber, Cristina Dracou, Judith Barash, Claudia Sengler, Alberto Martini, Isabelle Koné-Paut, Mohamad Maghnie, Angela Pistorio, Joseph Press, Carlos Da Silva, Natascia Di Iorgi |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Immunology Growth Standard score General Biochemistry Genetics and Molecular Biology Drug Administration Schedule Body Mass Index Sex Factors Rheumatology Internal medicine medicine Immunology and Allergy Juvenile Humans Lupus Erythematosus Systemic Longitudinal Studies Prospective Studies Age of Onset Prospective cohort study Child Glucocorticoids Growth Disorders Puberty Delayed Lupus erythematosus Anthropometry Cumulative dose business.industry Puberty medicine.disease Connective tissue disease Body Height Endocrinology Female Age of onset business Body mass index |
| Zdroj: | Annals of the rheumatic diseases. 71(4) |
| ISSN: | 1468-2060 |
| Popis: | To obtain longitudinal data on growth/puberty in a large-scale, multi-national prospective cohort of juvenile systemic lupus erythematosus (SLE).Data from 331/557 (59.4%) patients ≤18 years old with juvenile SLE in active phase, with anthropometric data available at four follow-up visits, were studied.There was a significant reduction in parent-adjusted height z score with time in females and males (p0.0001), with a significant gender difference (p0.0001) and with male height being most affected. Median body mass index z score peaked at 6 months and was still significantly above baseline after 26 months (p0.01), with no gender difference. Standardised height reduction was inversely related to age at onset. Females with onset age12 years had a median parent-adjusted height z score of -0.87 with no catch-up growth. At the end of the study, growth failure was seen in 14.7% of the females and 24.5% of the males. Height deflection (less than -0.25/year) was found in 20.7% of the females and 45.5% of the males. Delayed pubertal onset was seen in 15.3% and 24% of the females and males, respectively, and delayed/absent menarche was seen in 21.9%, while 36.1% of the females and 44% of the males had some degree of delayed pubertal development. Growth failure baseline determinants were previous growth failure (OR: 56.6), age at first visit ≤13.4 years (OR: 4.2) and cumulative steroid dose426 mg/kg (OR: 3.6).The children at risk of having a negative effect on height and pubertal development are prepubertal and peripubertal children treated with400 mg/kg cumulative dose of corticosteroids. |
| Databáze: | OpenAIRE |
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