The Different Microbial Etiology of Prosthetic Joint Infections According to Route of Acquisition and Time After Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms

Autor: Benito, Natividad, Mur, Isabel, Ribera, Alba, Soriano, Alex, Rodriguez-Pardo, Dolors, Sorli, Luisa, Cobo, Javier, Fernandez-Sampedro, Marta, Dolores del Toro, Maria, Guio, Laura, Praena, Julia, Bahamonde, Alberto, Riera, Melchor, Esteban, Jaime, Mirena Baraia-Etxaburu, Josu, Martinez-Alvarez, Jesus, Jover-Saenz, Alfredo, Duenas, Carlos, Ramos, Antonio, Sobrino, Beatriz, Euba, Gorane, Morata, Laura, Pigrau, Carles, Horcajada, Juan P., Coll, Pere, Crusi, Xavier, Ariza, Javier, Garcia-Gonzalez, Merce, Perez-Villar, Ferran, Prats-Gispert, Laura, Ramirez-Hidalgo, Maria, De-la-Pena-Trigueros, Mireia, Lopez-Azkarreta, Inigo, Lopez-Martinez, Miriam, Lora-Tamayo, Jaime, Murillo, Oscar, Pedrero, Salvador, Amador, Juan, Garcia-Paino, Luis, Parrondo, Susana, Raya, Carmen, Moreno, Alfonso, Aranzazu Blanco-Martinez-de-Morentin, Maria, Genoveva Zapico-Aldea, Laura Rodriguez-Fernandez, Lozano, Luis, Munoz-Mahamud, Ernesto, Merino-Perez, Josu, Alier, Albert, Prim, Nuria, Puig, Luis, Aunon, Alvaro, Blanco, Antonio, Garcia-Canete, Joaquin, Parron-Cambero, Raul, Carmen Farinas, M., Manuel-Bloque, Ricardo, Salas-Venero, Carlos, Campo-Loarte, Jesus, Munez-Rubio, Elena, Sanchez-Romero, Isabel, Escudero-Sanchez, Rosa, Ruiz-Carbajosa, Patricia, Gonzalez, Aranzazu, Carlos Gonzalez, Jose, Jordan, Marcos, Rivera, Alba, Marinescu, Carmen, Montaner, Francisco, Ramirez, Antonio, Corona, Pablo S., Lung, Maily, Puig-Asensio, Mireia, Angel Muniain-Ezcurra, Miguel, Penas-Espinar, Cecilia, Isabel Suarez, Ana, Jose Gomez, Maria, Lopez-Pliego, Macarena, REIPI Spanish Network Res Infect D, SEIMC Spanish Soc Infect Dis Clini
Přispěvatelé: Universidad de Cantabria, Institut Català de la Salut, [Benito N, Mur I] Unitat de Malalties Infeccioses, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. [Ribera A] Departament de Malalties Infeccioses, Hospital Universitari Bellvitge, Barcelona, Spain. [Soriano A] Departament de Malalties Infeccioses, Hospital Clínic Universitari, Barcelona, Spain. [Rodríguez-Pardo D, Pigrau C] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sorlí L] Departament de Malalties Infeccioses, Parc de Salut Mar, Barcelona, Spain., Vall d'Hebron Barcelona Hospital Campus
Rok vydání: 2019
Předmět:
0301 basic medicine
Etiology
retrospective study
coagulase negative Staphylococcus
lcsh:Medicine
Prosthesis
Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores]
medicine.disease_cause
0302 clinical medicine
revision arthroplasty
equipos y suministros::prótesis e implantes::prótesis articulares [TÉCNICAS Y EQUIPOS ANALÍTICOS
DIAGNÓSTICOS Y TERAPÉUTICOS]
non-fermenting Gram-negative bacterium
Bacteroides
Medicine
Pròtesis
Microorganismes - Resistència als medicaments
030212 general & internal medicine
Equipment and Supplies::Prostheses and Implants::Joint Prosthesis [ANALYTICAL
DIAGNOSTIC AND THERAPEUTIC TECHNIQUES
AND EQUIPMENT]
Candida
disease transmission
periprosthetic joint infection
biology
cons
immunosuppressive treatment
methicillin resistant Staphylococcus aureus
postoperative infection
Multidrug-Resistant Organisms
Articulacions artificials
General Medicine
Antimicrobial
Infeccions
infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estafilocócicas [ENFERMEDADES]
aged
female
risk factor
Staphylococcus aureus
Etiologia
Classification Schemes For Prosthetic Joint Infections
Articulacions - Cirurgia - Complicacions
fenómenos microbiológicos::fenómenos fisiológicos bacterianos::farmacorresistencia bacteriana::farmacorresistencia bacteriana múltiple [FENÓMENOS Y PROCESOS]
Charlson Comorbidity Index
Gram positive cocci
prospective study
musculoskeletal diseases
Bacilli
Microbiological Phenomena::Bacterial Physiological Phenomena::Drug Resistance
Bacterial::Drug Resistance
Multiple
Bacterial [PHENOMENA AND PROCESSES]
Prosthetic joint
030106 microbiology
microbial identification
bacterium culture
Virulence
Corynebacterium
Infections
Article
Mycobacterium
Microbiology
acute hematogenous infection
03 medical and health sciences
Enterobacteriaceae
male
bacterium isolation
Other subheadings::Other subheadings::/adverse effects [Other subheadings]
extended spectrum beta lactamase producing Enterobacteriaceae
Staphylococcus epidermidis
human
Propionibacterium acnes
bacteremia
Prosthetic Joint Infections
Antimicrobial Empirical Treatment
nonhuman
business.industry
bacterial virulence
lcsh:R
Infeccions per estafilococs
Streptococcus
biology.organism_classification
Classification schemes for prosthetic joint
major clinical study
Multiple drug resistance
osteoarthritis
multicenter study
arthroplasty
prosthesis implantation
Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Staphylococcal Infections [DISEASES]
observational study
Microbial Etiology
business
Enterococcus
Zdroj: J Clin Med . 2019 May 13;8(5):673
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Journal of Clinical Medicine
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Scientia
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Clinical Medicine, Vol 8, Iss 5, p 673 (2019)
Volume 8
Issue 5
ISSN: 2077-0383
Popis: The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)&mdash
including multidrug-resistant organisms (MDRO)&mdash
by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama&rsquo
s scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and &ldquo
positive intraoperative cultures&rdquo
(PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <
1 month, 2&ndash
3 months, 4&ndash
12 months, >
12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
Databáze: OpenAIRE
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