The effects of frusemide and probenecid on the pharmacokinetics of phenprocoumon
| Autor: | M. Böhm, Wilhelm Kirch, Edgar E. Ohnhaus, Heiner Mönig |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.drug_class medicine.medical_treatment Administration Oral Pharmacology Phenprocoumon Pharmacokinetics Oral administration Furosemide medicine Humans Pharmacology (medical) Drug Interactions Chromatography High Pressure Liquid Chemistry Probenecid Anticoagulant General Medicine Drug interaction Prothrombin Time Female Diuretic medicine.drug Half-Life |
| Zdroj: | European journal of clinical pharmacology. 39(3) |
| ISSN: | 0031-6970 |
| Popis: | We have studied the pharmacokinetics of phenprocoumon with and without co-administration of frusemide and probenecid in two groups of 17 healthy volunteers. Frusemide 40 mg b.i.d. for 7 days did not interact with phenprocoumon to a significant extent. Probenecid 500 mg q.i.d. for 7 days significantly accelerated the overall elimination of phenprocoumon, as indicated by a decrease in AUC from 295 to 157 micrograms.h.ml-1, and a reduction in the fraction of the dose excreted by the kidneys. The data are consistent with inhibition of the glucuronidation of phenprocoumon by probenecid. Its accelerated elimination may be a consequence of the increased formation of hydroxylated metabolites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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