Evaluation of the trophic effect of human placental polydeoxyribonucleotide on human knee skin fibroblasts in primary culture
| Autor: | G. Cattarini, S Gianoglio, S. Schiappacasse, E. L. Tonoli, L. Felli, F. Picchetta, Gian Carlo Schito, A. Pesce Schito, O. Muratore |
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| Rok vydání: | 1997 |
| Předmět: |
Pathology
medicine.medical_specialty Primary culture Microgram Placenta Human skin Biology Cell Line Andrology Cellular and Molecular Neuroscience Polydeoxyribonucleotides Pregnancy medicine Humans Knee primary tissue culture Molecular Biology Trophic level Pharmacology Wound Healing Cell Biology Fibroblasts Human placental polydeoxyribonucleotide (PDRN) primary tissue culture human skin fibroblasts wound healing Cell culture Molecular Medicine Female Wound healing human skin fibroblasts |
| Zdroj: | Cellular and molecular life sciences : CMLS. 53(3) |
| ISSN: | 1420-682X |
| Popis: | A simple assay capable of evaluating the trophic effect of growth factors or active principles on human skin diploid fibroblasts in primary culture has been developed. The results indicate that at physiological concentrations (20-100 micrograms/ml) a human placental polydeoxyribonucleotide (PDRN) preparation enhances the growth of human skin diploid fibroblasts of the knee in primary culture. This effect is consistently reproducible in the case of patients over 60 years of age, and may explain previously reported data on the successful clinical applications of human placental preparations, suggesting a selective benefit of PDRN in wound healing when compared to other treatments. |
| Databáze: | OpenAIRE |
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