Disparities in breast cancer tumor characteristics, treatment, time to treatment, and survival probability among African American and white women
| Autor: | Cecilia R. DeGraffinreid, Kevin Chu Foy, Electra D. Paskett, Maryam B. Lustberg, James L. Fisher, Darrell M. Gray |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Proportional hazards model business.industry Mortality rate medicine.medical_treatment Confounding Cancer Disease medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 Article Cancer registry 03 medical and health sciences 0302 clinical medicine Breast cancer Oncology 030220 oncology & carcinogenesis Internal medicine medicine Pharmacology (medical) Radiology Nuclear Medicine and imaging 030212 general & internal medicine business Mastectomy |
| Zdroj: | npj Breast Cancer, Vol 4, Iss 1, Pp 1-6 (2018) NPJ Breast Cancer |
| ISSN: | 2374-4677 |
| Popis: | African American (AA) women have a 42% higher breast cancer death rate compared to white women despite recent advancements in management of the disease. We examined racial differences in clinical and tumor characteristics, treatment and survival in patients diagnosed with breast cancer between 2005 and 2014 at a single institution, the James Cancer Hospital, and who were included in the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Cancer Registry in Columbus OH. Statistical analyses included likelihood ratio chi-square tests for differences in proportions, as well as univariate and multivariate Cox proportional hazards regressions to examine associations between race and overall and progression-free survival probabilities. AA women made up 10.2% (469 of 4593) the sample. Average time to onset of treatment after diagnosis was almost two times longer in AA women compared to white women (62.0 days vs 35.5 days, p Racial disparity: African Americans face delayed treatment African Americans with breast cancer wait longer to get treated and then live shorter than white women, a US cancer center’s records show. Electra Paskett and her colleagues from Ohio State University in Columbus examined racial differences in tumor characteristics and patient outcomes among the 4,593 women treated for breast cancer at their institution’s affiliated hospitals between 2005 and 2014. They found that the time between diagnosis and treatment onset was longer for African Americans — 62 days compared to 35.5 days for white women. African Americans were also more likely to have harder-to-treat forms of disease and they were less likely to undergo surgery. Even accounting for many of these factors, African American women still had worse outcomes, as measured by survival probability. The findings highlight the need address racial disparities in breast cancer treatment. |
| Databáze: | OpenAIRE |
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