Fact or Fiction? Adipose-Derived Stem Cells and Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus
| Autor: | Leslie A. Sadownik, Panteha Eshtiaghi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Web of science Cell Transplantation Treatment outcome MEDLINE Adipose tissue Vulvar Lichen Sclerosus 03 medical and health sciences 0302 clinical medicine medicine Humans Aged 030219 obstetrics & reproductive medicine integumentary system Platelet-Rich Plasma business.industry Obstetrics and Gynecology Mesenchymal Stem Cells General Medicine Middle Aged Dermatology Observational Studies as Topic Treatment Outcome 030220 oncology & carcinogenesis Platelet-rich plasma Female Stem cell business |
| Zdroj: | Journal of Lower Genital Tract Disease. 23:65-70 |
| ISSN: | 1526-0976 |
| DOI: | 10.1097/lgt.0000000000000440 |
| Popis: | The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS).PubMed/MEDLINE, Ovid, Web of Science, and clinicaltrials.gov were searched from inception up to May 7, 2018.Seven observational studies were identified, with a total of 98 patients. Both ADSCs and PRP were reported to improve symptoms, quality of life measures, as well as clinical and histological signs of vulvar LS. There is a strong risk of biased estimates of treatment effect.Current evidence is weak for ADSCs and/or PRP as treatment for vulvar LS. Further research is needed before recommending this therapy. |
| Databáze: | OpenAIRE |
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