An observational study of benzodiazepine prescription during inpatient alcohol detoxification for patients with vs. without chronic pretreatment with high-dosage baclofen

Autor:	Franck Questel, Vanessa Bloch, Laura Martinez, Frank Bellivier, Alexandra Dereux, Maeva Fortias, Xavier Declèves, Julien Azuar, Hélène Barreteau, Florence Vorspan, Jean-Pierre Lépine, Leslie Grichy
Rok vydání:	2018
Předmět:	Adult Male Baclofen Time Factors Alcohol Drinking medicine.drug_class medicine.medical_treatment Administration Oral Alcohol Alcohol use disorder 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Medicine Pharmacology (medical) 030212 general & internal medicine Medical prescription GABA Modulators Retrospective Studies Pharmacology Inpatients Benzodiazepine Diazepam Oxazepam business.industry Alcohol detoxification Middle Aged medicine.disease Substance Withdrawal Syndrome body regions Alcoholism Treatment Outcome chemistry High dosage GABA-B Receptor Agonists Anesthesia Female Observational study business 030217 neurology & neurosurgery
Zdroj:	Fundamental & Clinical Pharmacology. 32:200-205
ISSN:	0767-3981
DOI:	10.1111/fcp.12339
Popis:	High-dose baclofen is prescribed as a maintenance treatment to reduce alcohol use in patients with alcohol use disorder. Nevertheless, some patients still have massive alcohol intakes and require inpatient alcohol withdrawal. To compare the oral dose of benzodiazepine prescribed to manage alcohol withdrawal symptoms in patients with vs. without steady-state pretreatment with high-dose baclofen. Retrospective chart review study. Prescribed benzodiazepine dose expressed in diazepam-equivalent was compared between groups. Thirty-one patients were assessed in the high-dose maintenance baclofen group and compared to 31 matched patients not receiving baclofen. No statistically significant difference was evident between groups regarding levels of benzodiazepines prescribed. The mean diazepam-equivalent dose during the first 7 days was 294 ± 149 mg in the baclofen group vs. 310 ± 133 mg (t-test = 0.440, P = 0.661) in matched controls. Steady-state high-dose baclofen before an inpatient alcohol cessation hospitalization does not lower the needed benzodiazepine dose in the management of alcohol withdrawal symptoms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdef3703b706e399e4fb172c89e45f01 https://doi.org/10.1111/fcp.12339 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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