Electrophysiological abnormalities as indicators of early-stage pathology in Primary Progressive Aphasia (PPA): A case study in semantic variant PPA

Autor:	Aneta Kielar, Priyanka P. Shah-Basak, Dianne K. Patterson, Regina Jokel, Jed A. Meltzer
Rok vydání:	2022
Předmět:	Aphasia Primary Progressive Arts and Humanities (miscellaneous) Brain Humans Neurology (clinical) behavioral disciplines and activities Temporal Lobe Language Semantics
Zdroj:	Neurocase. 28(1)
ISSN:	1465-3656
Popis:	Language induced and spontaneous oscillatory activity was measured using MEG in a patient with the semantic variant of Primary Progressive Aphasia (svPPA) and 15 healthy controls.The patient showed oscillatory slowing in the left anterior temporal lobe (ATL) that extended into non-atrophied brain tissue in left and right frontal areas. The white matter connections were reduced to the left and right ATL and left frontal regions, exhibiting electrophysiological abnormalities. Altered diffusion metrics in all four language tracts, indicted compromised white matter integrity. Task-related and spontaneous oscillatory abnormalities can indicate early neurodegeneration in svPPA, providing promising targets for intervention.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdef270d4be178de17d64eebdef254b6 https://pubmed.ncbi.nlm.nih.gov/35230912 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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