| Autor: |
Eckold, C, Kumar, V, Weiner, J, Alisjahbana, B, Riza, A-L, Ronacher, K, Coronel, J, Kerry-Barnard, S, Malherbe, ST, Kleynhans, L, Stanley, K, Soeroto, A, Permana, H, Imaculata, S, Apriani, L, Ugarte-Gil, C, Walzl, G, van Crevel, R, Wijmenga, C, Critchley, JA, Dockrell, HM, Haks, M, Cliff, JM, Malherbe, S, Dockrell, H, Cliff, J, Moore, D, Griffiths, U, Laurence, Y, Aarnouste, R, Netea, M, Ruesen, C, Lachmandas, E, Kaufmann, S, Beigier, M, Golinski, R, Joosten, S, Ottenhoff, T, Vrieling, F, Smith, B, van der Spuy, G, Loxton, A, Chegou, N, Bosman, M, Thiart, L, Nitu, F, Wagman, C, Editoiu, C, Tshivhula, H, Selamolela, M, Prins, N, du Plessis, W, van Rensburg, I, du Toit, L, Critchley, J, Bazavan, I, Pearson, F, Grint, D, Florescu, A, McAllister, S, Hill, P, Verrall, A, Ioana, M, Riza, A, Cioboata, R, Dudau, M, Olteanu, M, Mota, M, Popa, SG, Firanescu, A, Popa, A, Gheonea, I, Bicuti, S, Lepadat, A, Capitanescu, I, Vladu, I, Papurica, M, Clenciu, D, Bicu, M, Streba, C, Demetrian, A, Ciurea, M, Cimpoeru, A, Ciocoiu, A, Dorobantu, S, Olaru, M, Plesea, R, Popescu, EL, Valutanu, I, Cucu, M, Streata, I, Burada, F, Serban-Sosoi, S, Panduru, N, Nicoli, E, Ciontea, M, Tataru, T, Dubreu, V, Stamatoiu, L, Lopez, S, Gunawan, Y, Limascca, R, Ruslami, R, Villaizan, K, Castro, B, Flores, J, Solano, W, Soetedjo, N, Santoso, P, Dewi, N, Chaidir, L, Koesoemadinata, R, Susilawati, N, Annisa, J, Livia, R, Yunivita, V |
| Přispěvatelé: |
TANDEM (Concurrent Tuberculosis and Diabetes Mellitus, unraveling the causal link, and improving care) Consortium |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases, 72, 1, pp. 69-78
Clinical Infectious Diseases
Clinical Infectious Diseases, 72, 69-78 |
| ISSN: |
1058-4838 |
| DOI: |
10.1093/cid/ciaa751 |
| Popis: |
Background People with diabetes have an increased risk of developing active tuberculosis (TB) and are more likely to have poor TB-treatment outcomes, which may impact on control of TB as the prevalence of diabetes is increasing worldwide. Blood transcriptomes are altered in patients with active TB relative to healthy individuals. The effects of diabetes and intermediate hyperglycemia (IH) on this transcriptomic signature were investigated to enhance understanding of immunological susceptibility in diabetes-TB comorbidity. Methods Whole blood samples were collected from active TB patients with diabetes (glycated hemoglobin [HbA1c] ≥6.5%) or IH (HbA1c = 5.7% to
Our study shows that people with diabetes and tuberculosis have altered peripheral immune profiles compared to people with only tuberculosis, and that these differences also exist in patients with intermediate hyperglycemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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