Analysis of the association ofCOL2A1andIGF-1with mandibular prognathism in a Chinese population
| Autor: | G. Luo, Feng Xue, A B M Rabie |
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| Rok vydání: | 2014 |
| Předmět: |
Male
China Heterozygote Linkage disequilibrium Candidate gene Guanine Adolescent Genotype Orthodontics Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Linkage Disequilibrium Gene Frequency Humans Genetic Predisposition to Disease Insulin-Like Growth Factor I Allele Collagen Type II Allele frequency Genetic association Genetics Polymorphism Genetic Adenine Homozygote Haplotype Haplotypes Otorhinolaryngology Case-Control Studies Prognathism Hong Kong Female Surgery Oral Surgery Genome-Wide Association Study |
| Zdroj: | Orthodontics & Craniofacial Research. 17:144-149 |
| ISSN: | 1601-6335 |
| DOI: | 10.1111/ocr.12038 |
| Popis: | Structured Abstract Objective In this study, we performed a case–control association analysis to determine whether the candidate genes COL2A1 and IGF-1 are susceptibility genes for mandibular prognathism (MP). Methods Eleven and five single-nucleotide polymorphisms (SNPs) located in COL2A1 and IGF-1, respectively, were selected and genotyped in 211 cases and 224 controls. The individual SNPs and the relevant haplotypes were analyzed and tested for an association with MP, to identify genes potentially associated with MP. Results In the analysis of individual SNPs, the SNP rs1793953 in the COL2A1 gene showed a possible association with MP with regard to allelic frequency and genotypic distribution (p = 0.031; p = 0.025, respectively) in the 211 cases and 224 controls. The A allele of rs1793953 was associated with a significantly decreased risk of MP (OR: 0.74; 95% CI: 0.58–0.97). Linkage disequilibrium and haplotype analysis revealed that MP was not associated with haplotypes that included the rs1793953 alleles. IGF-1 gene did not show the association with MP. Conclusion An association between polymorphism in the COL2A1 gene and MP was observed. The results suggested that the COL2A1 gene could be a new susceptibility gene for use in the study of genetic risk factors for MP. |
| Databáze: | OpenAIRE |
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