Characteristics and severity of asthma in children with and without atopic conditions: A cross-sectional study

Autor: Arabkhazaeli, Ali, Vijverberg, Susanne J. H., van Erp, Francine C., Raaijmakers, Jan A. M., van der Ent, Cornelis K., Maitland van der Zee, Anke H., Sub Gen. Pharmacoepi and Clinical Pharm, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology
Přispěvatelé: Sub Gen. Pharmacoepi and Clinical Pharm, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Pediatrics
Allergy
Hay fever
Eczema
population
Severity of Illness Index
immune system diseases
Prevalence
gender
Family history
Non-U.S. Gov't
Netherlands
risk
education.field_of_study
child
emergency ward
family history
Research Support
Non-U.S. Gov't
Exacerbation
cohort analysis
drug therapy
Child
Preschool
Female
hypothesis
Atopic condition
Cohort study
Research Article
medicine.medical_specialty
corticosteroid
Population
Research Support
Food allergy
nitric oxide
pollen allergy
medicine
Journal Article
Hypersensitivity
Humans
cross-sectional study
Pediatrics
Perinatology
and Child Health
FeNO
human
education
Asthma
childhood
business.industry
asthma
medicine.disease
respiratory tract diseases
parent
Cross-Sectional Studies
allergic disease
quality of life
antihistaminic agent
Pediatrics
Perinatology and Child Health
Exhaled nitric oxide
business
Zdroj: BMC Pediatrics [E], 15(172). BioMed Central
BMC Pediatrics
BMC Pediatrics [E], 15(1), 172. BioMed Central
ISSN: 1471-2431
Popis: BACKGROUND: Childhood allergic diseases have a major impact on a child's quality of life, as well as that of their parents. We studied the coexistence of reported allergies in children who use asthma medication. Additionally, we tested the hypothesis that asthma severity is greater among children with certain combinations of co-morbid allergic conditions. METHODS: For this cross-sectional study, 703 children (ages 4 to 12 years) from the PACMAN cohort study were selected. All of the children were regular users of asthma medication. The study population was divided into nine subgroups according to parental-reported allergies of the child (hay fever, eczema, food allergy or combinations of these). In order to assess whether these subgroups differed clinically, the groups were compared for child characteristics (age, gender, family history of asthma), asthma exacerbations in the past year (oral corticosteroids (OCS) use; asthma-related emergency department (ED) visits), asthma control, fractional exhaled nitric oxide level (FeNO), and antihistaminic usage. RESULTS: In our study, 79.0 % of the parents reported that their child suffered from at least one atopic condition (hay fever, food allergy and eczema), and one quarter of the parents (25.6 %) reported that their child suffered from all three atopic conditions. Having more than one atopic condition was associated with an increased risk of OCS use (OR = 3.3, 95 % CI = 1.6 - 6.6), ED visits (OR = 2.3, 95 % CI = 1.2 - 4.6) in the past year and inadequate short term asthma control (OR = 1.9, 95 % CI = 1.3 - 2.8). CONCLUSIONS: Children who use asthma medication often also have other allergic conditions. Parental reported allergies were associated with a higher risk of more severe asthma (more asthma complaints and more asthma exacerbations).
Databáze: OpenAIRE
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