Maternal residence near municipal waste incinerators and the risk of urinary tract birth defects
| Autor: | Christine Monfort, Mireille Chiron, Elisabeth Robert-Gnansia, Sylvaine Cordier, Cécile Chevrier, Martine Hours, Lucie Anzivino-Viricel, Anne Lehébel, Emmanuelle Amar |
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| Přispěvatelé: | Forgeron, Christine, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre des Malformations Rhône-Alpes, REMERA, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche sur les Transports et leur Sécurité (INRETS), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes ( GERHM ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -IFR140-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement ( UMRESTTE ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Recherche sur les Transports et leur Sécurité ( INRETS ) -Institut de Veille Sanitaire (INVS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Hazardous Waste
Municipal solid waste MESH : Prenatal Exposure Delayed Effects [ SDV.TOX ] Life Sciences [q-bio]/Toxicology Incineration 010501 environmental sciences 01 natural sciences 0302 clinical medicine MESH: Pregnancy Pregnancy Surveys and Questionnaires Epidemiology MESH: Urinary Tract MESH: Incineration MESH : Female 030212 general & internal medicine Urinary Tract MESH : Incineration [SDV.BDD]Life Sciences [q-bio]/Development Biology 2. Zero hunger education.field_of_study MESH : Pregnancy Outcome MESH: Dioxins MESH: Infant Newborn Pregnancy Outcome MESH : Questionnaires MESH : Urinary Tract [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Congenital Abnormalities MESH : Adult MESH: Case-Control Studies [SDV.TOX] Life Sciences [q-bio]/Toxicology Prenatal Exposure Delayed Effects [SDV.TOX]Life Sciences [q-bio]/Toxicology Female MESH: Hazardous Waste France Adult medicine.medical_specialty MESH : Case-Control Studies MESH: Air Pollution Population Dioxins MESH : Infant Newborn Congenital Abnormalities MESH: Prenatal Exposure Delayed Effects 03 medical and health sciences MESH : Dioxins Environmental health Air Pollution [SDV.BDD] Life Sciences [q-bio]/Development Biology medicine Humans [ SDV.BDD ] Life Sciences [q-bio]/Development Biology MESH : Hazardous Waste education MESH : France 0105 earth and related environmental sciences MESH: Humans business.industry MESH: Questionnaires MESH : Humans Public Health Environmental and Occupational Health Infant Newborn Ecological study MESH: Adult MESH : Congenital Abnormalities medicine.disease MESH: Pregnancy Outcome MESH: France MESH : Pregnancy 13. Climate action [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Case-Control Studies MESH : Air Pollution Residence [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Female Waste disposal |
| Zdroj: | Occupational and Environmental Medicine Occupational and Environmental Medicine, 2010, 67 (7), pp.493-9. ⟨10.1136/oem.2009.052456⟩ Occupational and Environmental Medicine, BMJ Publishing Group, 2010, 67 (7), pp.493-9. 〈10.1136/oem.2009.052456〉 Occupational and Environmental Medicine, BMJ Publishing Group, 2010, 67 (7), pp.493-9. ⟨10.1136/oem.2009.052456⟩ |
| ISSN: | 1351-0711 |
| DOI: | 10.1136/oem.2009.052456 |
| Popis: | International audience; OBJECTIVES: Waste incineration releases a mixture of chemicals with high embryotoxic potential, including heavy metals and dioxins/furans, into the atmosphere. In a previous ecological study we found an association between the risk of urinary tract birth defects and residence in the vicinity of municipal solid waste incinerators (MSWIs). The objective of the present study was to specifically test this association. METHODS: A population-based case-control study compared 304 infants with urinary tract birth defects diagnosed in the Rhône-Alpes region (2001-2003) with a random sample of 226 population controls frequency-matched for infant sex and year and district of birth. Exposure to dioxins in early pregnancy at the place of residence, used as a tracer of the mixture released by 21 active waste incinerators, was predicted with second-generation Gaussian modelling (ADMS3 software). Other industrial emissions of dioxins, population density and neighbourhood deprivation were also assessed. Individual risk factors including consumption of local food were obtained by interviews with 62% of the case and all control families. RESULTS: Risk was increased for mothers exposed to dioxins above the median at the beginning of pregnancy (OR 2.95, 95% CI 1.47 to 5.92 for dioxin deposits). When only interviewed cases were considered, risk estimates decreased mainly because the non-interviewed cases were more likely to live in exposed residential environments (OR 2.05, 95% CI 0.92 to 4.57). The results suggest that consumption of local food modifies this risk. CONCLUSIONS: This study confirms our previous observation of a link between the risk of urinary tract birth defects and exposure to MSWI emissions in early pregnancy and illustrates the effect of participation bias on risk estimates of environmental health impacts. |
| Databáze: | OpenAIRE |
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