| Autor: |
Kazuhiro Noguchi, Yasuhiro Ikawa, Mika Takenaka, Yuta Sakai, Toshihiro Fujiki, Rie Kuroda, Hiroko Ikeda, Satoko Nakada, Kozo Nomura, Seisho Sakai, Masaki Fukuda, Raita Araki, Yukitoshi Takahashi, Taizo Wada |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Pediatric hematology and oncology. |
| ISSN: |
1521-0669 |
| Popis: |
Opsoclonus-myoclonus syndrome associated with neuroblastoma (OMS-NB) is a refractory paraneoplastic syndrome which often remain neurological sequelae, and detailed pathogenesis has remained elusive. We encountered a pediatric patient with OMS-NB treated by immunosuppressed therapy who showed anti-glutamate receptor δ2 antibody and increased B-cells in cerebrospinal fluid (CSF), and multiple lymphoid follicles containing abundant Bcells in tumor tissue. Unbiased B-cell receptor repertoire analysis revealed identical B-cell clone was identified as the dominant clone in both CSF and tumor tissue. These identical B-cell clone may contribute to the pathogenesis of OMS-NB. Our results could facilitate the establishment of pathogenesis-based treatment strategies for OMS-NB. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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